Senior Manager / Associate Director, Portfolio Strategy & Market Research

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Senior Manager, Portfolio Strategy & Market Research

Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti‑angiogenesis effects associated with blocking VEGF into a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets with multifold higher affinity when in the presence of both PD‑1 and VEGF.

Summit has begun its clinical development of ivonescimab in non‑small cell lung cancer (NSCLC), with three active Phase III trials :

HARMONi is a Phase III clinical trial which intends to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR‑mutated, locally advanced or metastatic non‑squamous NSCLC who have progressed after treatment with a 3rd generation EGFR TKI (e.g., osimertinib).

HARMONi‑3 is a Phase III clinical trial which is designed to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first‑line metastatic NSCLC.

HARMONi‑7 is a Phase III clinical trial which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first‑line metastatic NSCLC whose tumors have high PD‑L1 expression.

Ivonescimab is an investigational therapy that is not approved by any regulatory authority in Summit’s license territories, including the United States and Europe. Ivonescimab was approved for marketing authorization in China in May 2024. Ivonescimab was granted Fast Track designation by the US Food & Drug Administration (FDA) for the HARMONi clinical trial setting.

Overview of Role :

The Senior Manager, Portfolio Strategy & Market Research position reports to the Executive Director, Portfolio Strategy to support strategic planning activities by providing actionable recommendations based on assessments of markets and competitors, both existing and potential.

Role and Responsibilities :

• Deliver strategic market and competitive intelligence insights, scenario planning and impact assessment based on in‑depth research through presentations and reports to the Executive Director of Portfolio Strategy and various internal management teams to allow effective strategic and tactical decision‑making and implementation,
• Conduct in‑depth research and analysis on market participants’ products and positioning
• Supply the market and competitive intelligence component of strategic planning and proactively makes recommendations to Executive Director of Portfolio Strategy concerning key intelligence items that require further consideration. Responsible for understanding real‑time changes to the competitive and market landscape and communicating the impacts of these changes to the organization
• Partner with internal business stakeholders to enhance their use of strategic analysis, market insights, and competitor intelligence
• Maintain a strong working knowledge of which factors, data points, and other inputs meaningfully impact commercial results in solid tumor oncology markets
• Contribute to development of product revenue for early forecasting modelling of new indications through 18 months prior to a potential commercial product launch
• Develop market research plan to inform business strategy, including qualitative, quantitative research and competitive intelligence projects, and executing market research to drive high quality insights and recommendations to inform strategy
• Communicate and align key internal stakeholders around market research objectives and outputs
• Determine appropriate research methodology to address business objectives
• Lead market research projects, including vendor selection, design, execution, interpretation, and dissemination of market research results to deliver insights
• Manage vendor partnerships including negotiating costs, on‑boarding, ensuring accountability, and timely project execution
• Contribute to strategic planning including situation analysis, market access plans, brand plans, market assessments and present strategic plan to internal teams
• Gather and synthesize data on consumers, competitors and marketplace and consolidate information into actionable items, reports and presentations
• Conduct in depth assessment on new indications, including market viability, competitive landscape, drivers and barriers, and financial projections
• Maintain up‑to‑date knowledge of data sources, evaluating their credibility and potential utility, and leverages them across the company where appropriate
• Maintain an in‑depth knowledge of designated markets and trends through synthesis of reports, market research, data manipulation and financial modelling and analysis. Create and maintain a Knowledge Repository to maintain all insights and data information for internal stakeholders to access
• Leverage best in class methodologies to analyze market, epidemiology and statistical data using modern and traditional methods. Drive survey design and analysis for ad hoc projects and implement new surveys or changes
• Track and interpret customer trends and share the implications throughout the company
• Deliver strategic analytical support to R&D, Commercial, Corporate Strategy, Regulatory and BD on an ad‑hoc basis to solve problems and inform strategy
• Cultivate strong relationships with key internal stakeholders to proactively identify emerging needs and business challenges
• Partner with Commercial, Operations, Regulatory, Biostatistics, Corporate Strategy, IT, and Legal to ensure that the needs of the business is addressed
• All other duties as assigned

Experience, Education and Specialized Knowledge and Skills :

The pay range for this role is $153,000-$180,000 annually. Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and / or other applicable variable compensation.

Summit does not accept referrals from employment businesses and / or employment agencies in respect of the vacancies posted on this site. All employment businesses / agencies are required to contact Summit’s Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring any candidates to Summit.

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