Director, Business Development

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Location : On-Site 4 days per week at our Menlo Park, CA, Miami, FL or Princeton, NJ office

About Summit

Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets with multifold higher affinity when in the presence of both PD-1 and VEGF.

Summit has begun its clinical development of ivonescimab in non‑small cell lung cancer (NSCLC), with three active Phase III trials :

• HARMONi is a Phase III clinical trial which intends to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR‑mutated, locally advanced, or metastatic non‑squamous NSCLC who have progressed after treatment with a 3rd generation EGFR TKI (e.g., osimertinib).
• HARMONi‑3 is a Phase III clinical trial which is designed to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first‑line metastatic NSCLC.
• HARMONi‑7 is a Phase III clinical trial which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first‑line metastatic NSCLC whose tumors have high PD‑L1 expression.

Ivonescimab is an investigational therapy that is not approved by any regulatory authority in Summit’s license territories, including the United States and Europe. Ivonescimab was approved for marketing authorization in China in May 2024. Ivonescimab was granted Fast Track designation by the US Food & Drug Administration (FDA) for the HARMONi clinical trial setting.

Overview of Role

The Director, Business Development plays a critical role in advancing the company’s external innovation strategy by identifying, evaluating, and supporting the execution of strategic partnerships or licensing opportunities. This leader works closely with the Department Head and cross‑functional teams to drive company growth through external collaborations, to include joint clinical trials. The ideal candidate brings strong scientific & business acumen, transaction & alliance experience, R&D operational capabilities and the ability to navigate complex strategic landscapes with speed, rigor, and creativity. This is a hands‑on, end‑to‑end experience role, where you’ll engage on strategy, searching and securing opportunities from a business development perspective, as well as operationalizing and contributing to the department’s maintenance of strategic alliances.

Role and Responsibilities

Partner with R&D, Clinical, Commercial, Market Planning, Legal, and Finance teams to assess strategic fit, risks, and integration requirements for potential deals.

Maintain a deep understanding of the oncology competitive landscape, emerging modalities, and deal trends to inform BD strategy and prioritization. Partner with internal experts and strategy team members to shape future scenarios and action plans.

Evaluate external assets, platforms, and technologies aligned with the company’s oncology strategy and pipeline priorities. Ability to triangulate and prioritize opportunities.

Support or lead deal processes including diligence, external communication with potential collaborators, coordinating contracting and related requirements, and preparation of executive materials.

Contribute to collaboration alliance activities or clinical trial project oversight with partner, governance and performance tracking of key alliances, ensuring alignment with strategic objectives and operational milestones.

Prepare high‑impact presentations and recommendations for the Department Head or executive leadership, translating complex data into actionable insights & plans. Ability to serve on joint committees and / or facilitate alliance working groups.

Bring a proactive, solutions‑oriented approach to identifying whitespace opportunities and shaping external growth initiatives.

Experience, Education and Specialized Knowledge and Skills

The pay range for this role is $184,500 – $230,000 per year. Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and / or other applicable variable compensation.

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