SeniorPrincipal Scientist, Antibody Discovery

Senior / Principal Scientist Antibody Discovery

Germantown MD Full Time

Nexagen Search is representing a biotechnology company that is hiring for an Senior / Principal Scientist Antibody Discovery to join their research team in Rokville MD. This role will contribute to early-stage discovery programs and will employ molecular biology biochemistry and cell-based techniques to support the development of novel therapeutic candidates

Key Responsibilities

• Lead discovery-stage research for pipeline therapeutic programs.
• Identify and validate novel antibody hits using phage / yeast display and / or hybridoma platforms.
• Develop and execute screening funnels to assess binding selectivity and functional activity across biochemical and cellular assays.
• Generate expression constructs and produce / purify candidate biologics in mammalian expression systems to support discovery workflows.
• Characterize antibody candidates through in vitro assays including binding analyses epitope assessment and functional cell-based readouts.
• Analyze and interpret experimental data to inform hit prioritization lead selection and next-step discovery strategies.
• Troubleshoot experimental challenges optimize assay conditions and refine discovery tools and methods.
• Present research findings to internal project teams and represent the program at scientific meetings as needed.
• Collaborate with cross-functional teamsincluding translational medicine medical sciences CMC and external CRO partnersto advance discovery candidates.
• May mentor or supervise research associates and scientists contributing to discovery programs.

Core Qualifications & Experience

Compensation : 100-150k base; 15% annual bonus

Recruiter in Charge : Jeff Caskey

Managing Partner

Required Experience :

Staff IC

Key Skills

Machine Learning,Python,Data Science,AI,R,Research Experience,Sensors,Drug Discovery,Research & Development,Natural Language Processing,Data Analysis Skills,Toxicology Experience

Employment Type : Full Time

Experience : years

Vacancy : 1