PK/PD Modeling / Pharmacometrics LeadMercor • Sherman, Texas, US
No longer accepting applications
PK / PD Modeling / Pharmacometrics Lead
Mercor • Sherman, Texas, US
1 day ago
Job type
- Part-time
- Remote
Job descriptionWho we’re looking for Deep hands-on experience in PK, PD, exposure–response modeling , and ideally population PK or QSP . - Expert at model fitting, sensitivity analysis, and identifying non-plausible parameter spaces. - Can evaluate the validity of dose–exposure predictions and detect high-risk extrapolations. - Comfortable designing model evaluation rubrics that distinguish between acceptable vs. non-credible outputs. - Able to articulate how quantitative checks should complement narrative decision logic. Nice-to-have : Experience supporting translational or clinical pharmacology leads in dose justification. - Familiarity with integrating nonclinical PK / PD data (2-species GLP → human FIH extrapolation). ### Experience level ~8–12 years of quantitative pharmacology experience in pharma, CROs, or modeling consultancies . - Strong portfolio in population PK / PD exposure–response , and parameter estimation using NONMEM, Monolix, or equivalent tools. - Demonstrated ability to interpret model results for decision-making, not just fit data. - Can create fit-for-purpose models and critique model structures or assumptions under uncertainty. ### Expectations Design and refine micro-evaluations for PK / PD performance (curve fits, parameter checks, error taxonomies). - Encode quantitative sanity checks into model rubrics for automated evaluation. - Define failure conditions (e.g., unsafe extrapolation, poor coverage curves, invalid assumptions). Inputs we give : PK / PD datasets, tox summaries, and performance prompts (e.g., “fit exposure–response curves, interpret safety margins”). - Example model outputs from automated systems. Expected outputs : Quantitative Rubrics : clear thresholds for acceptable parameter fits, coverage curve quality, and model integrity checks. - Golden Fit Examples : representative “ideal” PK / PD model outputs and visualizations for calibration. - Error Taxonomy : structured list of typical modeling or fitting errors, with root-cause annotations. - Meta-Layer Commentary : short note per rubric capturing how expert modelers recognize implausible or unsafe fits beyond numeric error values. ### Engagement Model & Compensation Contract / part-time , remote, outcome-based deliverables.
This person complements the client’s “Translational / Clinical Pharmacology Decision-Maker” team by grounding dose selection and exposure–response analysis in
- quantitative structure and parameter plausibility
###
Create a job alert for this search
Modeling • Sherman, Texas, US
Related jobs
Empower Healing in a Dynamic Setting : Join Our Inpatient Physical Therapy Team in McKinney, Texas.Imagine your daily efforts being the key to helping someone take their initial steps post-surgery, ...Show more
At Powerback, we're on a mission to improve lives.As the leader in physical, occupational, speech, and respiratory therapies, we help older adults stay active and thrive while providing essential t...Show more
Physical Therapist — Pediatric Clinic near Pottsboro, TX.Join a supportive, multi-disciplinary pediatric clinic that takes a true team approach to therapy.
Work with children and young adults ages 0...Show more
The Physical Therapy Tech position will have responsibility for assisting the Physical Therapist or Physical Therapy assistant with daily patient physical therapy treatment.Will provide assistance ...Show more
The Physical Therapy Tech position will have responsibility for assisting the Physical Therapist or Physical Therapy assistant with daily patient physical therapy treatment.Will provide assistance ...Show more
Are you a Physical Therapist looking to thrive in a supportive, balanced environment? Join ATI, a leader in Physical Therapy, where you'll be part of a team redefining MSK care.With a mission to de...Show more
Are you passionate about the patient experience? At HCA Healthcare, we are committed to caring for patients with purpose and integrity.
We care like family! Jump-start your career as a Nuclear Medic...Show more
Technical Lead Backend Engineering.BeeHyv is a boutique software engineering firm helping product companies, mid-market enterprises, and PE-backed firms modernize systems, build cloud-native platf...Show more
Are you a compassionate and dependable individual who is looking for a career that means something? Do you have a passion for serving others and a desire to know you are making a difference? If so,...Show more
Full Time Day Shift Position, Monday - Friday, 10-hr.Hours are from 6 : 30am - 5 : 00pm.NO CALL REQUIRED for this position.
May Be Eligible for a Sign On Bonus of $20K.Experience the HCA Healthcare diff...Show more
Arial, sans-serif;"> Clinical Supervisor (...Show more
Neurology – Independent Practice Track (MedCBO Supported).MedCBO is a Colorado-based healthcare business infrastructure company that empowers independent physician groups across the United States t...Show more
Pivot at Beacon Hill - Denison, TX.We are seeking PRN PTs for the following locations : .Renaissance Care Center - Gainesville.
Work today, get paid tomorrow with Payactiv!.Pivot Rehabilitation is a t...Show more Transform Lives and Embrace New Adventures : Join Our Inpatient Physical Therapy Team in McKinney, Texas.Imagine a role where each day allows you to help someone take their first steps towards recov...Show more MedCBO is a Colorado-based healthcare business infrastructure company that empowers independent physician groups across the United States to launch, manage, and scale their practices.We provide a c...Show more 
Our client is a leading force in advancing safer, smarter AI technology.Their work has been featured in.They’ve built a global community of expert contributors and have already paid out more ...Show more
Varying Shifts (United States of America).The NP / PA, Surgical functions in a collaborative practice with physician(s) in the outpatient and inpatient setting.
Autonomously performs patient assessmen...Show more
Join Our Team as a Medical Billing and Collections Rep!.Are you a problem-solver with a passion for helping others? As a Medical Billing and Collections Representative, you'll play a key role in re...Show more
DPT / Inpatient / Outpatient Physical Therapist
MLee Healthcare Staffing and Recruiting, Inc • McKinney, TX, United States
Full-time
Last updated: 30+ days ago • Promoted
Physical Therapist (PT)
Powerback Rehabilitation • McKinney, TX, USA
Full-time +1
Last updated: 30+ days ago • Promoted
Physical Therapist
PediaStaff • Pottsboro, Texas, United States
Full-time +1
Quick Apply
Last updated: 16 days ago
Physical Therapy Tech - PRN -GTC Prosper
Surgery Partners • Prosper, TX, United States
Full-time
Last updated: 30+ days ago • Promoted
Physical Therapy Tech - PRN -GTC Prosper
Methodist McKinney Hospital • Prosper, TX, United States
Full-time
Last updated: 30+ days ago • Promoted
Physical Therapist
ATI Physical Therapy • McKinney, TX, United States
Full-time
Last updated: 30+ days ago • Promoted
Nuclear Medicine Tech
Medical City Dallas • McKinney, TX, United States
Full-time +1
Last updated: 30+ days ago • Promoted
Technical Lead (McKinney)
BeeHyv Software • McKinney, TX, US
Part-time
Last updated: 5 hours ago • Promoted • New!
Med Tech
Sagora Senior Living • Sherman, TX, United States
Full-time
Last updated: 4 days ago • Promoted
EP Lab Tech
Medical City Heart & Spine Hospitals • McKinney, TX, United States
Full-time +1
Last updated: 30+ days ago • Promoted
Clinical Supervisor, BCBA - Up to 5K Sign on Bonus
Accel Therapies • Mckinney, TX, US
Full-time
Last updated: 17 hours ago • Promoted • New!
Neurology – Independent Practice Track (MedCBO Supported)
MedCBO, Inc • Gunter, TX, United States
Full-time
Last updated: 13 days ago • Promoted
Physical Therapist (PT) PRN- Texoma
Cantex Continuing Care Network • Denison, TX, United States
Full-time
Last updated: 30+ days ago • Promoted
DPT / Inpatient and Outpatient Physical Therapist
MLee Healthcare Staffing and Recruiting, Inc • McKinney, TX, United States
Full-time
Last updated: 30+ days ago • Promoted
Dermatologist – Independent Practice Track (MedCBO Supported)
MedCBO, Inc • Gunter, TX, United States
Full-time
Last updated: 13 days ago • Promoted
Engineer
Quality Talent Group • Sherman, Texas, United States
Full-time
Quick Apply
Last updated: 8 days ago
NP / PA, Surgical (Orthopedics)
Cook Children's Health Care System • Prosper, TX, United States
Full-time
Last updated: 4 days ago • Promoted
Medical Billing & Collections Rep
ARstrat LLC • Denison, TX, United States
Full-time
Last updated: 30+ days ago • Promoted