PK/PD Module expert: Translational / Clinical Pharmacology Decision-MakerMercor • DeKalb, Illinois, US
PK / PD Module expert : Translational / Clinical Pharmacology Decision-Maker
Mercor • DeKalb, Illinois, US
22 hours ago
Job type
- Full-time
- Remote
Job descriptionWho we’re looking for Has owned FIH starting dose, SAD / MAD design, and Phase 2 dose selection for multiple assets. - Participated in governance or review boards, defending dose / exposure rationale in front of senior leadership or regulators. - Demonstrates ability to balance nonclinical → clinical translation : tox, PK, PD, potency, and MoA. - Can articulate the real decision calculus behind dose selection (safety, pharmacology, speed-to-proof). - Capable of turning narrative judgment into explicit decision rules and rubrics for AI training and evaluation. ### Experience level ~10+ years in major biopharma or biotech (e.g., Lilly, Roche, AbbVie, Amgen, Novartis, GSK, Regeneron, Vertex, Incyte, Gilead) or in specialized translational pharmacology consulting. - Has personally led FIH dose and / or SAD / MAD escalation for ≥2–3 assets. - Proven governance experience : IND sign-off, dose justification memos, exposure–response presentations. - CV or track record includes statements like _“led clinical pharmacology strategy and FIH dose selection”_ or _“accountable for exposure–response in Phase 1 / 2.”_ - Avoid pure modeling profiles; the ideal expert has decision accountability , not just analytical skill. ### Expectations Write “golden” FIH dose rationales and escalation strategies for representative programs. - Encode the decision heuristics and trade-offs used by senior translational leaders into structured guidance and rubrics. - Surface unwritten decision rules — when and why experienced teams override model-based recommendations. Inputs given : Representative drug programs or data packets (GLP tox summaries, PK / PD tables, potency & MoA context). - Target prompts for translational decision-making (e.g., _“Recommend FIH dose and escalation strategy given these data”_). Expected outputs : Golden Decision Memos : exemplar dose justification memos that reflect the level of reasoning and format expected from top-tier translational pharmacologists. - Decision Rubrics : scoring guides capturing acceptable vs. unsafe dose rationales, missed edge cases, or failure modes. - Meta-Layer Commentary : short narrative explaining unspoken heuristics — how senior teams weigh risk tolerance, potency data, or tox uncertainty.
The client is seeking an external expert who brings a
- decision-maker’s mindset
- — someone who has personally driven translational pharmacology choices under governance and uncertainty.
###
Create a job alert for this search
Clinical Pharmacology • DeKalb, Illinois, US
Related jobs
LocumJobsNetwork is working with CompHealth to find a qualified Hematology and Oncology MD in DeKalb, Illinois, 60115!.Some locum assignments can be as short as a day, others, years.Some are far fr...Show more
THE ARMY HEALTH CARE ADVANTAGE As a member of the Army health care team, you’ll receive benefits that you won’t be able to get in a civilian career.
Challenging Work Feel inspired with great case di...Show more
Endocrinology Physician at Healthcare United summary : .A Board Eligible / Board Certified Endocrinologist is sought to join an established team in Dekalb, Illinois, providing outpatient care for patie...Show more
At Northwestern Medicine, every patient interaction makes a difference in cultivating a positive workplace.This patient-first approach is what sets us apart as a leader in the healthcare industry.A...Show more
THE ARMY HEALTH CARE ADVANTAGE As a member of the Army health care team, you’ll receive benefits that you won’t be able to get in a civilian career.
Challenging Work Feel inspired with great case di...Show more
Must be a licensed Physical Therapist to apply.Exciting opportunity with Renewal Rehab!.Join a leading therapy organization with 30+ years of excellence in care and team development.Why You'll Love...Show more
Dekalb, Illinois (One hour from Chicago).Healthcare United is seeking a.Board Eligible / Board Certified Endocrinologist.
The selected candidate will provide dedicated support to an existing.Work alon...Show more
Medical Director Needed in Dekalb, ILWe work with a plasma donation center in Dekalb, IL.We have an open position for a Medical Director (MD or DO) to join us 4 hours a week.No specialty or experie...Show more
Athletico's Greater Purpose is to empower people, inspire hope and transform lives.We accomplish this by providing exceptional, progressive, and cost-effective care that emphasizes education and pr...Show more
Join an established Primary Care practice.Perform patient assessment and assign diagnosis based on recorded assessment data and current scientific and current research.
Establish plan of care and im...Show more
Some locum assignments can be as short as a day, others, years.Some are far from home, others are local.Whatever it is you're looking for, we offer true opportunities, not just postings.CompHealth ...Show more
We are currently seeking talented professionals interested in Physical Therapy (PT) in Home Health Setting.If you are eager to join a growing agency with opportunities for unlimited financial poten...Show more
Oral & Maxillofacial Surgeons for Northern Illinois, the practice of Dr.David Junck DDS, is looking for an associate to help them continue to grow their full-scope practice in Sycamore, IL.The part...Show more
Medical Experts - AI Training Role.Our client is a leading force in advancing safer, smarter AI technology.Their work has been featured in.
They have built a global community of expert contributors ...Show more
Some locum assignments can be as short as a day, others, years.Some are far from home, others are local.Whatever it is you're looking for, we offer true opportunities, not just postings.CompHealth ...Show more
LocumJobsOnline is working with CompHealth to find a qualified Hematology and Oncology MD in DeKalb, Illinois, 60115!.Some locum assignments can be as short as a day, others, years.Some are far fro...Show more
Join an established Primary Care practice.Perform patient assessment and assign diagnosis based on recorded assessment data and current scientific and current research.
Establish plan of care and im...Show more
Cytotechnologist ( ASCP ) ( CT ).Cytotechnologist to join our team and play a crucial role in diagnosing diseases, with a particular focus on cancer detection.
In this position, you will examine and...Show more
Locum Physician (MD / DO) - Hematology and Oncology in DeKalb, IL
LocumJobsNetwork • DeKalb, IL, US
Full-time +1
Last updated: 30+ days ago • Promoted
Active Entomologist
US Army • Big Rock, IL, United States
Full-time
Last updated: 30+ days ago • Promoted
Endocrinology Physician
Healthcare United • Dekalb, IL, USA
Full-time
Last updated: 30+ days ago • Promoted
Physical Therapist-Pelvic Health Full-time 12k Sign-on Bonus
Northwestern Memorial HealthCare • Dekalb, IL, United States
Full-time
Last updated: 30+ days ago • Promoted
Active Entomologist
United States Army • Big Rock, IL, United States
Full-time
Last updated: 28 days ago • Promoted
Physical Therapist - Per Diem
Renewal Rehab • DeKalb, IL, United States
Full-time
Last updated: 30+ days ago • Promoted
Endocrinologist Needed Near Dekalb, IL (1 hour West Chicago)
Healthcare United • DeKalb, IL, United States
Full-time
Last updated: 30+ days ago • Promoted
Physician / Medical Director / Illinois / Locum tenens / Medical Director in Dekalb, IL Job
Samuel Contract Staffing LLC • Dekalb, IL, US
Full-time
Last updated: 30+ days ago • Promoted
Physical Therapist- Dekalb, IL
Athletico Physical Therapy • Dekalb, IL, United States
Full-time
Last updated: 30+ days ago • Promoted
Advanced Practice Provider Primary Care
OSF Healthcare • POPLAR GROVE, IL, US
Permanent
Last updated: 30+ days ago • Promoted
Hematologist / Oncologist Is Needed for Locums Assistance in Illinois
CHG Healthcare • DeKalb, IL, US
Permanent
Last updated: 30+ days ago • Promoted
Home Health Physical Therapist-Somonauk, IL
CRS Home Therapy, P.C • Somonauk, IL, United States
Full-time
Last updated: 4 days ago • Promoted
Private Practice in Chicago Suburb Expanding and Seeking Associate!
Oral & Maxillofacial Surgeons for Northern Illinois • Sycamore, IL, United States
Full-time
Last updated: 8 days ago • Promoted
Medical Experts
Quality Talent Group • DeKalb, Illinois, United States
Full-time
Quick Apply
Last updated: 7 days ago
Locum Physician (MD / DO) - Hematology and Oncology in DeKalb, IL
CompHealth • DeKalb, IL, United States
Full-time
Last updated: 19 days ago • Promoted
Locum Physician (MD / DO) - Hematology and Oncology in DeKalb, IL
LocumJobsOnline • DeKalb, IL, US
Full-time +1
Last updated: 30+ days ago • Promoted
Advanced Practice Provider Primary Care
OSF HealthCare • Poplar Grove, IL, United States
Full-time
Last updated: 30+ days ago • Promoted
ASCP - Cytotechnologist
MLee Healthcare Staffing and Recruiting, Inc • Kingston, IL, United States
Full-time +1
Last updated: 4 days ago • Promoted