Principal Scientist, Medical Physicist

Working with Us

Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here uniquely interesting work happens every day in every department. From optimizing a production line to the latest breakthroughs in cell therapy this is work that transforms the lives of patients and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. Read more : a Bristol Myers Squibb company is a dynamic biotechnology company headquartered in San Diego CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team RayzeBio aims to be the global leader in radiopharmaceuticals .

The Principal Scientist Medical Physicist will be responsible for applying their expertise in radiopharmaceutical (RPT)-specific modeling to the research and development of new drugs and therapies. Their focus will be on radiopharmaceutical dose modelling and analyzing data from in vitro and vivo studies as well as clinical diagnostic and therapeutic studies. The candidate will be responsible for leading translational dosimetry analysis such as physiologically based pharmacokinetics or compartmentalization modelling. The candidate will also provide technical support including dosimetry calculations and work in collaboration with internal stakeholders as well as external vendors and experts.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

Work closely with Radiation Biophysics / Medical Physics to support all aspects of internal dosimetry analysis in discovery and development of radiopharmaceutical imaging and therapeutic agents.

Work closely with Discovery to design experiments and perform dosimetric data analysis from imaging modalities like PET (positron emission tomography) and SPECT (single-photon emission computed tomography) to assess drug uptake and distribution

Identify and advise best practices and standardization processes for image data quality control in preclinical research aligned with current guidance in literature.

Analyze preclinical and clinical imaging data to advance the translation of animal-to-human dose projection.

Explore new technologies and modelling approaches to improve the development of radiopharmaceuticals such as novel radioisotopes including alpha-emitters.

Contribute to the advancement of medical physics knowledge in the field of radiopharmaceuticals.

Provide technical support training and problem-solving solutions to cross-functional teams as needed.

Education and Experience

Advanced degree in Medical Physics or Engineering (PhD preferred) with didactic training in RPT biodistribution kinetics and dose modelling.

Minimum of 6 years of experience in molecular imaging and RPT dose modelling research or 3 years of extensive RPT-specific publications (10).

Experience with radiopharmaceuticals as therapeutics in oncology and experience with alpha-emitters strongly desired

Skills and Qualification

Subject Matter Expert in mathematical pharmacokinetic modeling and its application in radiopharmaceutical research and development.

Technical skills with dosimetry software coding and simulation / modeling / statistical tools (e.g. 3D-RD-S MIM MIRDcalc OLINDA Torch GATE SIMIND SAAM II SimBiology Python Matlab R SPSS ITK-snap 3D slicer Elastix etc.)

Demonstrated ability to communicate clearly and think creatively when problem-solving on multidisciplinary projects.

Proven track record for coordinating and aligning cross-functional stakeholders to deliver on corporate timeline in a team environment.

Excellent communications skills and ability to present and discuss imaging and dosimetry topics clearly and concisely including with scientific experts globally.

Demonstrated ability to organize prioritize and work effectively with minimal supervision in a constantly changing environment.

Recognized leadership skills professional ethics integrity and ability to maintain confidential information.

Willingness to travel when needed (10-15%) including conference attendance which may involve evening and weekend work.

Current knowledge of global dosimetry guidelines and passion for pioneering alpha-emitting radiotherapeutics a plus.

Physical Demands

While performing the duties of this job the employee is regularly required to sit reach with hands and arms and talk or hear. The employee must occasionally lift and / or move up to 50 pounds. Specific vision abilities required by this job include close vision and distance vision.

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If you come across a role that intrigues you but doesnt perfectly line up with your resume we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview :

• San Diego - RayzeBio - CA : $163788 - $198473

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job such as required skills where the job is performed the employees work schedule job-related knowledge and experience. Final individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits please visit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following : Medical pharmacy dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability life insurance supplemental health insurance business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays Global Shutdown Days between Christmas and New Years holiday up to 120 hours of paid vacation up to two (2) paid days to volunteer sick time off and summer hours flexibility. Parental caregiver bereavement and military leave. Family care services such as adoption and surrogacy reimbursement fertility / infertility benefits support for traveling mothers and child elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work Life-changing Careers

With a single vision as inspiring as Transforming patients lives through science every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture promoting global participation in clinical trials while our shared values of passion innovation urgency accountability inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential site-by-design field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role :

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles onsite presence is considered an essential job function and is critical to collaboration innovation productivity and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process reasonable workplace accommodations / adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation / adjustment prior to accepting a job offer. If you require reasonable accommodations / adjustments in completing this application or in any part of the recruitment process direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff customers patients and communities. As a result the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position please visit this page for important additional information : data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Required Experience :

Staff IC

Key Skills

Machine Learning,Python,Data Science,AI,R,Research Experience,Sensors,Drug Discovery,Research & Development,Natural Language Processing,Data Analysis Skills,Toxicology Experience

Employment Type : Full-Time

Experience : years

Vacancy : 1