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Oncology Principal Investigator
Oncology Principal InvestigatorPlexus Partners • San Jose, CA, US
Oncology Principal Investigator

Oncology Principal Investigator

Plexus Partners • San Jose, CA, US
30+ days ago
Job type
  • Full-time
Job description

Job Description

Oncologist / Principal Investigator - Clinical Research leadership


Location: Los Angeles, CA (relocation assistance provided)

Employment Type: Full-Time, On-Site

Salary: $700k-800k base salary, bonuses and incentives


Overview

We are representing an exceptional research-focused oncology organization seeking a Principal Investigator (PI) to oversee a highly experienced clinical team and drive breakthrough studies with biotech sponsors.


This is a full-time, research-only role, offering the opportunity to guide cutting-edge oncology trials in a fast-growing, data-driven clinical environment.


The position is ideal for an oncologist who wants to transition from purely clinical practice into a leadership role at the intersection of science, medicine, and industry, helping advance next-generation cancer therapies.


Key Responsibilities

  • Serve as the Principal Investigator for oncology trials across multiple modalities and sponsors.
  • Provide medical oversight, ensure patient safety, and maintain protocol compliance and data integrity.
  • Supervise and mentor sub-investigators, nurse practitioners, and clinical operations staff.
  • Collaborate closely with sponsors, CROs, and internal study teams to drive enrollment and site performance.
  • Support scientific and operational strategy, SOP refinement, and future site development.
  • Participate in investigator meetings, safety reviews, and regulatory inspections.


Ideal Candidate

  • MD or DO with board certification or eligibility in Hematology/Oncology (or related discipline).
  • 2+ years post-fellowship experience (early-career attendings encouraged to apply).
  • Demonstrated clinical excellence and the ability to manage oncology patients in a research setting.
  • Prior Sub-I or PI experience preferred but not required — full GCP training and mentorship provided.
  • Strong communication skills, collaborative mindset, and enthusiasm for research and innovation.
  • Must be committed to a full-time, on-site position.


Why This Opportunity

  • Exceptional Organization — culture of scientific rigor, integrity, and collaboration.
  • Exposure to Cutting-Edge Oncology Programs — work on next-generation therapeutic approaches.
  • Leadership Trajectory — opportunity to expand into multi-site or network-level leadership.
  • Competitive Compensation — highly attractive package with relocation and performance incentives.


This search is being managed exclusively by Plexus Partners.


Interested candidates can submit a CV or express interest in confidence to:


elliot@plexus-partners.com

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Oncology Principal Investigator • San Jose, CA, US

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