PK/PD Modeling / Pharmacometrics LeadMercor • Harrisonburg, Virginia, US
PK / PD Modeling / Pharmacometrics Lead
Mercor • Harrisonburg, Virginia, US
23 hours ago
Job type
- Part-time
- Remote
Job descriptionWho we’re looking for Deep hands-on experience in PK, PD, exposure–response modeling , and ideally population PK or QSP . - Expert at model fitting, sensitivity analysis, and identifying non-plausible parameter spaces. - Can evaluate the validity of dose–exposure predictions and detect high-risk extrapolations. - Comfortable designing model evaluation rubrics that distinguish between acceptable vs. non-credible outputs. - Able to articulate how quantitative checks should complement narrative decision logic. Nice-to-have : Experience supporting translational or clinical pharmacology leads in dose justification. - Familiarity with integrating nonclinical PK / PD data (2-species GLP → human FIH extrapolation). ### Experience level ~8–12 years of quantitative pharmacology experience in pharma, CROs, or modeling consultancies . - Strong portfolio in population PK / PD exposure–response , and parameter estimation using NONMEM, Monolix, or equivalent tools. - Demonstrated ability to interpret model results for decision-making, not just fit data. - Can create fit-for-purpose models and critique model structures or assumptions under uncertainty. ### Expectations Design and refine micro-evaluations for PK / PD performance (curve fits, parameter checks, error taxonomies). - Encode quantitative sanity checks into model rubrics for automated evaluation. - Define failure conditions (e.g., unsafe extrapolation, poor coverage curves, invalid assumptions). Inputs we give : PK / PD datasets, tox summaries, and performance prompts (e.g., “fit exposure–response curves, interpret safety margins”). - Example model outputs from automated systems. Expected outputs : Quantitative Rubrics : clear thresholds for acceptable parameter fits, coverage curve quality, and model integrity checks. - Golden Fit Examples : representative “ideal” PK / PD model outputs and visualizations for calibration. - Error Taxonomy : structured list of typical modeling or fitting errors, with root-cause annotations. - Meta-Layer Commentary : short note per rubric capturing how expert modelers recognize implausible or unsafe fits beyond numeric error values. ### Engagement Model & Compensation Contract / part-time , remote, outcome-based deliverables.
This person complements the client’s “Translational / Clinical Pharmacology Decision-Maker” team by grounding dose selection and exposure–response analysis in
- quantitative structure and parameter plausibility
###
Create a job alert for this search
Modeling • Harrisonburg, Virginia, US
Related jobs
Waynesboro, Virginia, United States.Physical Therapist (PT) | Outpatient | Full-time | Waynesboro, VA.At South River Rehab and Performance, we believe in the power of personalized care and passiona...Show more
Join a collegial independent private practice team of Physicians and APPs.Fast-track partnership in year 2, with multiple revenue streams.
State-of-the-art community hospital featuring the Da Vinci ...Show more
Lead a team of amazing Physical Therapists as the Clinic Director at BenchMark Physical Therapy in Greenville, VA!.I am passionate about serving our patients through high quality care and exceeding...Show more Join a close-knit, supportive medical community, where you'll work alongside fellowship-trained pain specialists in a cost-effective, patient-centered practice.
Looking for Experienced, Board-Certif...Show more 
Physical Therapist : Full-Time SIGN-ON BONUS UP TO $8,000 at Tender Touch Rehab Services, LLC summary : .We are seeking a passionate full-time Physical Therapist to join our team at Tender Touch Rehab...Show more
Virginia Physical Therapy License.We are an equal opportunity employer.Show more)
WHEN YOU WORK FOR US, WE WORK FOR YOU.With Titan Medical, you gain access to thousands of travel nursing and allied health jobs across the country.
You also get unmatched service.From the moment you...Show more
Up to $25,000 Sign On Incentive available!.At Powerback, we're on a mission to improve lives.As the leader in physical, occupational, speech, and respiratory therapies, we help older adults stay ac...Show more
By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Tak...Show more
Physical Therapist - Outpatient Ortho.Build Your Outpatient Physical Therapy Career with us!.At Drayer Physical Therapy, part of the Upstream Rehabilitation network, you can focus on patient care w...Show more
Are you a Nurse Practitioner or Physician Assistant who thrives on variety, adventure, and making an impact? Step into the role of Strategic Deployment Clinician, where you'll launch new partnershi...Show more
Bon Secours Mercy Health has expanded its footprint and is seeking dedicated and compassionate Advanced Practice Clinicians (Nurse Practitioners) to join our new Urgent Care clinic in Winchester, V...Show more
By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Tak...Show more
We’re looking for a motivated, patient-focused provider to join our growing team.MAs) as scribes / clinical assistants, based on patient load.
We can adjust midlevel provider assignments to suit...Show more
Up to $25,000 Sign On Incentive available!.At Powerback, we're on a mission to improve lives.As the leader in physical, occupational, speech, and respiratory therapies, we help older adults stay ac...Show more
Powerback - PERM - Augusta Nursing & Re -R12A29.All shown pay is an estimate based on pay package configuration, please apply now to learn more.Show more
Clinical Care Tech-Military Medics and Corpsmen.Starting Pay $46,097 (salary to commensurate with experience).Dept Behavioral Health / Develop.
Join our unique program to employ former military medics...Show more Bon Secours Mercy Health has expanded its footprint and is seeking dedicated and compassionate Advanced Practice Clinicians (Physician Assistants) to join our new Urgent Care clinic in Winchester, ...Show more
Physical Therapist
H2Health Careers • Waynesboro, Virginia, US
Full-time
Last updated: 30+ days ago • Promoted
550K Base | Private Practice Urology | 75K Recruitment Package | Robotics | VA
Jackson Physician Search • Fishersville, US
Full-time
Last updated: 30+ days ago • Promoted
Physical Therapist - Clinic Director
Upstream Rehabilitation • Greenville, VA, United States
Full-time
Last updated: 30+ days ago • Promoted
$800K+ Pain Management In GA | Physician Owned Practice Serving the CSRA Region
Jackson Physician Search • Waynesboro, US
Full-time
Last updated: 30+ days ago • Promoted
Physical Therapist : Full-Time SIGN-ON BONUS UP TO $8,000
Tender Touch Rehab Services, LLC • Bridgewater, NJ, USA
Full-time
Last updated: 30+ days ago • Promoted
Physical Therapy - PT SNF
Augusta Nursing & Rehab • Fishersville, VA, United States
Permanent
Last updated: 30+ days ago • Promoted
Travel - MRI Tech
Titan Medical (Nebraska) • Harrisonburg, VA, United States
Full-time
Last updated: 2 hours ago • Promoted • New!
Director of Rehab - Physical Therapy Assistant (PTA)
Genesis Healthcare Services • Fishersville, VA, United States
Full-time +1
Last updated: 4 days ago • Promoted
Sr. Plasma Center Tech / Phlebotmist
Biolife Plasma Services • Harrisonburg, VA, United States
Full-time
Last updated: 9 hours ago • Promoted • New!
Physical Therapist
Drayer Physical Therapy • Harrisonburg, VA, United States
Full-time +1
Last updated: 30+ days ago • Promoted
Strategic Deployment Clinician / Primary Care NP
Eventus WholeHealth • Harrisonburg, VA, United States
Full-time
Last updated: 30+ days ago • Promoted
Full-Time Advanced Practice Clinician (NP), Urgent Care
Bon Secours Mercy Health • Harrisonburg, US
Full-time
Last updated: 30+ days ago • Promoted
Sr. Plasma Center Tech / Phlebotmist
Biolife Plasma Services Careers • Harrisonburg, VA, United States
Full-time
Last updated: 5 hours ago • Promoted • New!
Dermatologist / Derm Path Opening
Gpac • Waynesboro, Virginia, United States
Full-time
Quick Apply
Last updated: 15 hours ago • New!
Director of Rehab - Physical Therapy Assistant (PTA)
Powerback Rehabilitation • Fishersville, VA, United States
Full-time +1
Last updated: 20 days ago • Promoted
Physical Therapy - PT SNF
Powerback - PERM - Augusta Nursing & Re -R12A29 • Fishersville, VA, United States
Permanent
Last updated: 4 days ago • Promoted
Clinical Care Tech-Military Medics and Corpsmen
Virginia Jobs • Harrisonburg, VA, United States
Full-time
Last updated: 17 days ago • Promoted
Full-Time Advanced Practice Clinician (PA), Urgent Care
Bon Secours Mercy Health • Harrisonburg, US
Full-time
Last updated: 30+ days ago • Promoted