Scientist

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The University of Miami / UHealth Department of SCCC has an exciting opportunity for a Full Time Transgenic and Gene Targeting Scientist to work at the UHealth campus in Miami Fl.

CORE JOB SUMMARY

The Scientist SOM supports the Universitys research goals and objectives by engaging in complex experiments and investigations in a range of areas depending on specialty and interests. Moreover an employee in this position contributes to the scientific community and promotes the Universitys reputation as a leader in the field.

CORE JOB FUNCTIONS

Oversees research employees students and other relevant staff. Authors scientific publications technical and agency reports and patent applications. Assists in the development of training materials for research staff. Plans experiment and records and analyzes findings. Prepares research proposals and funding applications. Ensures that all activities are in compliance with applicable quality and regulatory standards. Maintains current knowledge of relevant scientific and technical developments. Presents ongoing work and findings to colleagues at academic conferences. Adheres to University and unit-level policies and procedures and safeguards University assets. This list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary.

CORE QUALIFICATIONS

Education : Ph.D. M.D. or other doctoral level degree in relevant field

Experience : Minimum 10 years of relevant experience

Knowledge Skills and Attitudes :

• Skill in collecting organizing and analyzing data.
• Ability to recognize analyze and solve a variety of problems.
• Ability to exercise sound judgment in making critical decisions.

Department Specific Functions

The Sylvester Comprehensive Cancer Center is currently seeking a Transgenic and Gene Targeting Scientist who will join the Cancer Modeling Shared Resource. This translational Facility provides qualified cost effective and state-of-the art services to foster cancer research advancements and accelerate the discovery of tailored antitumor therapies. We are seeking a dynamic individual who would like to participate in the creation and development of new service lines in a busy and fast-paced environment mainly focused on the generation of state-of-the-art services necessary to generate novel mouse models of cancer using advanced techniques and technologies to produce and manipulate customized genetically engineered rodents. This person will directly assist the Director in running and implementing these new genetic engineering services to support researchers in the field of functional genomics and disease modeling. The successful candidate will also participate in the planning and implementation of genome editing and transgenic projects including being responsible for the experimental design procurement and validation of the services provided and models produced under the direction of Dr. Bilbao.

The following job description reflects additional support that this position must provide. Specific responsibilities of the position include and are not limited to :

Ensure the implementation of the transgenic and genetic engineering services. These services include the use of CRISPR / Cas9 targeting to produce gene knockouts conditional knockouts single-point mutations and insertions and gene fusions also simultaneously mutating multiple genes in a single experiment; transgenic mice generation by injecting plasmid or bacterial artificial chromosome DNA constructs into inbred and outbred mouse strains; knockout (KO) mice conditional knockout (CKO) mice knock-in (KI) mice generation using traditional ES cell targeting including C57BL6 ESCs; ES cell tetraploid and iPS cell microinjection; rederivation; embryo and sperm cryopreservation; in vitro fertilization; tail biopsy and genotyping. Independently conduct research projects based on reviews of scientific literature and recent advances in related fields while contributing original / novel ideas of major methodological significance to projects designing key experiments and developing new techniques while ensuring the adequate integration with the rest of the services offered by the facility to provide state-of-the-art in vivo services. Advises supports and trains relevant personnel on technical procedures techniques and reagents needed generating the required SOPs to support functional genomics services. Manages and coordinates the activities of assigned project(s) with responsibility for results in terms of costs methods and resources while evaluates best ways to improve desired outcomes together with the director. Work with the director and the team to develop adapt and implement new services and state-of-the-art technologies while maintaining up-to-date knowledge of the genetic engineering and in vivo transgenesis field including major advances and emerging trends. Adhere to University and unit-level policies and procedures; safeguard University assets; participate in University / outside educational training as required. Perform other duties as requested.

Department Specific Qualifications

Education : Ph.D. M.D. or other doctoral level degree in molecular biological veterinary or biomedical sciences.

Experience : Minimum 10 years of relevant experience in field of genetic engineering and / or animal models. Experience in service provision and / or management in a research core facility is preferred.

Knowledge Skills and Attitudes :

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The University of Miami offers competitive salaries and a comprehensive benefits package including medical dental tuition remission and more.

UHealth-University of Miami Health System South Floridas only university-based health system provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center we are proud to serve South Florida Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching research and patient care. Were the challenge youve been looking for.

The University of Miami is an Equal Opportunity Employer - Females / Minorities / Protected Veterans / Individuals with Disabilities are encouraged to apply. Applicants and employees are protected from discrimination based on certain categories protected by Federal law. Click here for additional information.

Job Status : Full time

Employee Type : Staff

Pay Grade : A14

Key Skills

Laboratory Experience,Immunoassays,Machine Learning,Biochemistry,Assays,Research Experience,Spectroscopy,Research & Development,cGMP,Cell Culture,Molecular Biology,Data Analysis Skills

Employment Type : Full-Time

Experience : years

Vacancy : 1