Senior Director, ADC Process Development

Senior Director, ADC Process Development

At Lilly, we unite caring with discovery to make life better for people around the world. We are seeking a Senior Director, ADC Process Development, to lead and expand our growing team of scientists and engineers focused on delivering Lilly's Antibody-Drug Conjugate (ADC) portfolio. This role will be responsible for driving the end-to-end development of small molecule payloads, linkers, and conjugation processes from preclinical through commercial.

This is a high-impact role that sits at the critical intersection of chemistry, engineering, and biologics, requiring technical excellence, strategic oversight, and strong team leadership.

Position Summary

The ideal candidate will bring deep expertise in small molecule process chemistry, combined with a strong track record of leadership in cross-functional and matrixed environments. This position plays a critical role in building a world-class ADC platform and advancing Lilly's pipeline of innovative medicines.

Key Responsibilities Include :

• Build and lead a multidisciplinary team of scientists and engineers, managing resources to meet project and program objectives.
• Develop and implement short- and long-term CMC strategies to support a growing portfolio pipeline, while balancing internal and external resource requirements and constraints.
• Collaborate with internal stakeholders (e.g., Discovery, Analytical, Drug Product, Quality, Regulatory, CMC PM) and external CDMOs to align and execute the CMC development plan.
• Create and update end-to-end capacity models, provide important data for business planning.
• Drive the design, scale-up, and tech transfer of small molecule payload and linker synthesis processes in support of ADC development.
• Oversee development and optimization of conjugation processes for early and late-stage clinical projects.
• Work with HSE to establish and enforce safety protocols for handling ADC payloads, linkers, and conjugates in development labs.
• Contribute to regulatory submissions (IND, IMPD, BLA / MAA), authoring high-quality CMC sections.
• Help drive innovation and evaluate emerging technologies to enhance platform capabilities.

Basic Requirements :

Additional Skills and Preferences :

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include : Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities).

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $156,000 - $228,800. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees.