High-Throughput Screening Research Associate II, III (Biodesigner II, III) (San Francisco)

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply.

Job Description : High-Throughput Screening Research Associate II, III (Biodesigner II, III)

Responsibilities :

• Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts.
• Develop and execute molecular biology workflows such as vector design and cloning, DNA / RNA extraction, RT-PCR, qPCR, and next-generation sequencing.
• Support cell culture activities and experiments in multiple cell lines, at small and large scales.
• Design and execute cell-based assays (AAV / lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays).
• Engineer and characterize cell-based systems using synthetic biology tools and techniques.
• Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity.
• Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches.
• Prepare summaries of data and present internally to colleagues and management.
• Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records.
• Author scientific reports and data summaries.
• Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization.

Qualifications :

Preference will be given to those who display :

If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team.

Please apply directly through LinkedIn.

Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.