Principal Scientist, Complex in vitro Systems, Predictive Toxicology

Overview

The Position

We advance science so that we all have more time with the people we love. Genentech, a member of the Roche Group, has been at the forefront of the biotechnology industry for more than 45 years, developing novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer and other serious illnesses. We believe that our employees are our most important asset and are dedicated to remaining a great place to work.

We are seeking a motivated scientist and leader for the new Ocular Modeling team within the Complex in vitro Systems (CiS) Laboratory. This role will be instrumental in designing, developing, and characterizing cutting-edge complex in vitro models (CIVM) of ocular systems to support the broader Development Sciences, Research, and Translational Medicine departments at Genentech. The successful candidate will apply their expertise in stem-cell based tissue systems, biomaterials, and bioengineering to create microphysiological models of ocular segments to improve predictive assessments of drug safety and efficacy in the ocular space.

This leadership role will focus on establishing and deploying innovative, state-of-the-art ocular models to support both discovery and preclinical development portfolios. This includes evaluating drug candidates for ocular safety, understanding disposition, developing biomarkers, and assessing pharmacodynamic responses relevant to ocular diseases. The Head of Ocular Modeling will be responsible for setting the strategic direction for ocular modeling within CiS, driving scientific innovation, fostering key collaborations, and mentoring junior scientists to build a high-performing team.

The Opportunity

As a member of the Complex in vitro Systems (CiS) team, you will be :

• Developing and implementing the strategic roadmap for ocular modeling within CiS, ensuring alignment with organizational drug discovery and development objectives.
• Leading, mentoring, and developing a high-performing and motivated team of scientists who collectively design, develop, and characterize advanced ocular in vitro models, such as retinal organoids, organ-on-chip, and other microphysiological systems, to address critical questions in ocular drug discovery and development.
• Providing scientific guidance, teaching lab techniques, and ensuring professional growth and career development for junior team members with care and commitment.
• Acting as a primary liaison between the CiS team and internal research teams, translational medicine, and drug discovery units at Genentech and Roche to maximize the impact of strategic lab activities across ocular-focused projects.
• Facilitating and managing partnerships with external collaborators, including academic institutions, consortiums, and Contract Research Organizations (CROs) to advance ocular modeling capabilities.
• Sharing research in the form of peer-reviewed papers and presentations in cross-functional forums, internal meetings, and external conferences to communicate platform capabilities, progress, and outcomes related to ocular modeling.

Who You Are

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of California is $141,500 - $262,900 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company\'s policy prohibits unlawful discrimination, including but not limited to discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form for Accommodations for Applicants.

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