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Scientist III, Computational Pathology

Scientist III, Computational Pathology

Spectraforce TechnologiesSan Francisco, CA, United States
3 days ago
Job type
  • Full-time
Job description

Job Title : Scientist III, Computational Pathology

Duration : 1 year

Location : Can be Hybrid or remote in South San Francisco, CA

Purpose :

The Precision Medicine Pathology team drives the scientific strategy for translational tissue-based biomarker development & discovery target validation / MOA projects, leads pathology collaborative programs, conducts histopathological evaluation & analysis of IHC & spatial biology technologies, and provides technical / scientific leadership to histotechnicians & pathology scientists.

The successful candidate will have advanced knowledge and experience analyzing spatial transcriptomics and proteomics data generated on the CosMx SMI and PhenoCycler Fusion platforms.

Responsibilities :

  • Implementation of different scripts and pipelines for spatial transcriptomics data analysis and analysis of high-plex PhenoCycler Fusion (CODEX) images.
  • Independently performing end-to-end high-plex image analysis (tissue classification, cell segmentation, detection of marker positivity, cell phenotyping, unsupervised clustering, neighborhood analysis, proximity analysis).
  • Acting as a subject matter resource and training other team members in spatial analysis tasks.
  • Collaborating with pathologists and digital pathology scientists to support spatial biology projects.
  • Presenting the results and findings from spatial biology studies to stakeholders.

Qualifications :

  • MSc, PhD, or equivalent degree in biological sciences / computational biology / engineering / computer science / informatics
  • Fluency in Python and R
  • Experience in implementing and utilizing open-source scripts and pipelines for high-plex image analysis
  • Experience in quantitative digital pathology analysis platforms such as Halo, Visiopharm, QuPath
  • Close familiarity with tissue microscopic anatomy and histology (normal and diseased) is a plus
  • Excellent verbal communication skills are required including the demonstrated ability to effectively and clearly summarize results for presentation and report generation
  • Strong motivation, attention to detail, ability to think independently and fully integrate into a high achieving team environment
  • Ability to multi-task and manage multiple projects
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    Scientist Iii • San Francisco, CA, United States

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