Medical Director, Oncology – Medical Affairs

Medical Director, Oncology – Medical Affairs

Rezolute is a late‑stage rare disease biopharmaceutical company focused on developing transformative therapies for patients living with severe metabolic and endocrine disorders. Our mission is to bring hope and meaningful solutions to patients and families affected by rare and difficult‑to‑treat diseases through scientific innovation, collaboration, and integrity. Rezolute’s lead investigational therapy, RZ358 (ersodetug), is a fully human monoclonal antibody in late‑stage clinical development for the treatment of congenital and acquired forms of hyperinsulinism (HI). As Rezolute expands its medical and scientific focus into tumor hyperinsulinism (tumor HI) most commonly related to pancreatic neuroendocrine tumors (insulinomas) or paraneoplastic hypoglycemia (NICTH), the company is committed to advancing novel therapeutic strategies that address this rare and complex form of hypoglycemia associated with insulin‑secreting tumors and related oncologic disorders.

The

Medical Director, Oncology – Medical Affairs

will serve as Rezolute’s internal medical and scientific expert for tumor HI. This individual will play a pivotal role in developing and executing the Medical Affairs strategy that bridges oncology and endocrinology, advancing understanding and awareness of hypoglycemia in oncologic conditions. This role will lead internal disease‑state and product education, guide cross‑functional launch readiness, and provide scientific leadership for engagement with oncology and endocrinology key opinion leaders (KOLs). The Medical Director will partner closely with field‑based Senior Medical Science Liaisons (MSLs) and colleagues across Clinical Development, Regulatory Affairs, Commercial, and Market Access to ensure scientific excellence, alignment, and execution across all medical initiatives.

Key Responsibilities

Medical Strategy & Leadership

Partner in shaping and delivering Rezolute’s Medical Affairs strategy for RZ358 intumor HI.

Serve as the internal disease area expert for hypoglycemia in the oncology setting, providing strategic input into launch readiness, data generation, and scientific communication.

Collaborate with Clinical Development and Commercial teams to ensure medical strategy supports both clinical evidence needs and market preparedness.

Contribute to the development of publication plans, data dissemination strategies, and scientific platform. Assist with integrating insights gathered from field interactions into Medical Affairs strategy, launch readiness plans, and scientific communication priorities.

Partner with senior Medical Affairs leadership to ensure consistent messaging, training, and field alignment across all medical initiatives.

Internal Education & Training

Equip internal teams with the knowledge and confidence to meaningfully engage the medical and patient community through targeted disease and product education. Function as the primary trainer for scientific and clinical content related to hyperinsulinism pathophysiology, RZ358 mechanism of action, clinical data, and competitive landscape.

Ensure internal teams are equipped to engage credibly and compliantly with healthcare professionals.

Mentor and coach MSLs to enhance their scientific expertise and strategic engagement capabilities.

External Engagement & Thought Leader Collaboration

Build and maintain strong peer‑to‑peer relationships with leading oncologists, neuroendocrine tumor specialists, and endocrinologists focused on tumor‑related hypoglycemia.

Support the identification, engagement, and development of key opinion leaders (KOLs) and other external experts across oncology, endocrinology, and neuroendocrine disease communities.

Participate in and represent Rezolute at relevant oncology and endocrinology congresses, advisory boards, and symposia to communicate emerging science and gather medical insights.

Provide scientific leadership for investigator‑initiated studies (IIS), data generation efforts, and collaborative research opportunities focused on hyperinsulinism.

Capture and synthesize medical insights from field teams and external experts to inform strategy, publications, and future development programs.

Medical Affairs Execution

Collaborate with field‑based MSLs and cross‑functional launch teams to execute medical education, data dissemination, and stakeholder engagement plans for RZ358. Assist with the development of standard response documents and support Medical Information system execution.

Provide medical oversight for advisory board content, educational programs, and medical materials, ensuring scientific accuracy and compliance.

Provide ongoing scientific support to the Medical Information function through drafting, review, and refinement of standard response documents and FAQs.

Contribute to the development of scientific slide decks, FAQs, and other materials for internal and external use.

Compliance & Governance

Ensure all Medical Affairs activities adhere to Rezolute SOPs, regulatory standards, and applicable industry codes of practice.

Support medical / legal / regulatory (MLR) and promotional review activities, serving as a medical reviewer for scientific and promotional materials, ensuring accuracy, balance, and alignment with regulatory and compliance principles.

Support and partner cross‑functionally with commercial pharmacovigilance to ensure safety reporting activities are alignment with health authority requirements and company policy. Act as a visible ambassador for Rezolute’s mission, values, and ethical standards in all professional interactions.

Required Qualifications

MD, DO, or equivalent advanced clinical degree with board certification or strong expertise in Oncology, Adult Endocrinology, or related medical specialties.

Minimum of 8 years of experience in Medical Affairs within the biopharmaceutical industry, ideally with experience in oncology, endocrine‑oncology, or neuroendocrine tumors.

Demonstrated success developing and executing medical strategies for launch‑stage or commercialized rare disease, oncology or endocrinology products.

Proven success in developing and executing medical strategies for launch‑stage or rare oncology products.

Strong understanding of neuroendocrine tumor biology, tumor‑induced hypoglycemia, and mechanisms of insulin‑secreting malignancies.

Proven ability to translate complex scientific data into clear, actionable insights.

Demonstrated collaboration skills in a fast‑paced, matrixed organization.

Excellent communication, leadership, and presentation skills.

Willingness and ability to travel domestically and internationally (approximately up to 50%).

Preferred Experience And Attributes

Prior experience supporting oncology or endocrinology product launches, particularly in rare tumor indications or metabolic‑oncology interfaces.

Established professional relationships within oncology, endocrinology, and neuroendocrine communities.

Experience mentoring or leading field medical teams.

Experience supporting MLR / PRC reviews or Medical Information processes preferred.

Strategic thinker with strong execution and organizational skills.

High integrity, accountability, and a deep commitment to Rezolute’s mission to improve the lives of patients with rare and complex diseases.

Rezolute (RZLT) currently anticipates the base salary for the Medical Director, Oncology Medical Affairs role could range from

$275,000 to $300,000

and will depend, in part, on the successful candidate’s geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company’s discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience and geographical location of the selected candidate. Rezolute offers competitive compensation, stock options and a rich benefits package.

Qualifying employees are eligible to participate in benefit programs such as :

Health Insurance (Medical / Dental / Vision)

Disability, Life & Long‑Term Care Insurance

Holiday Pay

Tracking Free Vacation Program

401(k) Plan Match

Educational Assistance Benefit

Fitness Center Reimbursement

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.

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