Postdoctoral Fellow - Hematopoietic Biology & Malignancy (Dr. Casellas' Lab)

Overview

Postdoctoral Fellow - Hematopoietic Biology & Malignancy (Dr. Casellas' Lab) at Komen Graduate Training Program UT MDACC. The Laboratory of B Cell Biology and Nanotherapies seeks a highly motivated Structural Biologist with expertise in Computational Biology to join our team at MD Anderson Cancer Center. The successful candidate will leverage RF diffusion, protein modeling, and energy interaction analyses to optimize Nanobodies and design de novo binders targeting cancer.

Antibody-based immunotherapies such as CAR T cells and T cell engagers have transformed cancer treatment. Our lab focuses on developing therapeutics against both cell-surface and intracellular tumor antigens, with a commitment to clinical translation and ongoing antibody-based trials.

Responsibilities

• Design and optimize Nanobody binders using AI-based structural modeling (e.g., AlphaFold, RF diffusion) to evaluate antigen interactions.
• Apply computational approaches to predict energy landscapes and improve binder affinity and specificity.
• Integrate and analyze single-cell sequencing datasets (scRNA-seq, ATAC-seq, BCR-seq) to inform target biology and guide therapeutic design.
• Collaborate closely with experimental scientists to support ongoing preclinical and translational projects.

Qualifications

Position Information

MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000, depending on years of postgraduate experience. Benefits include medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and recognition programs.

EEO Statement

All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.

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