Senior Director, Statistical Programming

Senior Director, Statistical Programming

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When our people share why they joined Rapport and love it here, it comes down to three things : the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).

Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder.

The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are!

Your Impact

Lead and manage the Statistical Programming function across all stages of clinical development (Phase I-IV), from protocol development to submission and post-marketing activities.

Drive strategic planning and resource allocation for programming activities across studies and programs.

Oversee the design, development, validation, and documentation of SAS programs for data analysis, TFL (tables, listings, figures) generation, and CDISC deliverables (SDTM, ADaM).

Ensure compliance with industry standards (CDISC, ICH, FDA / EMA guidance) and Rapport SOPs.

Provide programming oversight for regulatory submissions (e.g., NDA / BLA / MAA), including eCTD packages, data packages, and reviewer guides.

Lead the development and implementation of programming standards, automation tools, and quality control processes.

Serve as a subject matter expert for programming strategy, data standards, and regulatory expectations.

Collaborate with Biostatistics leadership to ensure integration of statistical and programming workflows.

Build and mentor a high-performing programming team; provide coaching, career development, and performance management.

Manage outsourcing strategy and oversee deliverables from CROs and external vendors.

Contribute to cross-functional initiatives to improve data quality, efficiency, and innovation in clinical development.

Your Day-to-Day

Lead and manage the Statistical Programming function across all stages of clinical development (Phase I-IV), from protocol development to submission and post-marketing activities.

Drive strategic planning and resource allocation for programming activities across studies and programs.

Oversee the design, development, validation, and documentation of SAS programs for data analysis, TFL (tables, listings, figures) generation, and CDISC deliverables (SDTM, ADaM).

Ensure compliance with industry standards (CDISC, ICH, FDA / EMA guidance) and Rapport SOPs.

Provide programming oversight for regulatory submissions (e.g., NDA / BLA / MAA), including eCTD packages, data packages, and reviewer guides.

Lead the development and implementation of programming standards, automation tools, and quality control processes.

Serve as a subject matter expert for programming strategy, data standards, and regulatory expectations.

Collaborate with Biostatistics leadership to ensure integration of statistical and programming workflows.

Build and mentor a high-performing programming team; provide coaching, career development, and performance management.

Manage outsourcing strategy and oversee deliverables from CROs and external vendors.

Contribute to cross-functional initiatives to improve data quality, efficiency, and innovation in clinical development.

Must-Haves

Master’s or Bachelor’s degree in Computer Science, Statistics, Mathematics, Life Sciences, or a related field.

12+ years of experience in statistical programming within the biotech / pharmaceutical industry

Proven ability to build, lead, and develop high-performing programming teams, with a demonstrated track record of mentoring talent, fostering a collaborative culture, and aligning team objectives with broader organizational goals.

Expert-level proficiency in SAS (Base, Macro, STAT, GRAPH) and experience with CDISC standards (SDTM, ADaM).

Proven track record of supporting successful regulatory submissions (e.g., NDA, BLA, MAA).In-depth knowledge of clinical trial processes, GCP, regulatory requirements (FDA, EMA), and ICH guidelines.

Strong project management skills and ability to manage multiple priorities in a fast-paced environment.

Experience managing and developing high-performing teams, both internal and external (CRO / vendor).

Excellent interpersonal, communication, and leadership skills.

Familiarity with R, Python, or other programming languages is a plus.

Experience in Neurology or CSN highly desirable.

What Makes Rapport Special

Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start.

We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.

Your perspective matters. Stick your neck out, share your ideas – we work as a team.

We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with.

Leadership that CARES – about you, your growth + development.

We’re bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together.

Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!

You get to be YOU! Show up as you are and make every day count.

Your Compensation

We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this? We tell you about our hiring range now - we expect the hiring range for this role to be $265,000 to $290,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.

Hybrid Work Environment

We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection.

Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Note to Employment Agencies : Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

CCPA disclosure notice can be found here.

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