Senior Scientist / Principal Scientist, Proteomics, Discovery Technologies

JOB DESCRIPTION

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Overview :

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Position Summary :

The Scientist in the Multiomics Group, within Discovery Technologies, will be joining a dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. This scientist will work closely with the Molecular Characterization and Discovery Proteomics teams to design studies, execute analyses, and interpret data to support the various research programs for identified targets.

The successful candidate is expected to demonstrate expertise with various innovative, high throughput, high content molecular platforms profiling protein, DNA and RNA along with basic molecular biology techniques. This scientist will drive breakthrough research using cutting-edge high throughput protein platforms leading large-scale protein profiling studies from biomarker discovery through clinical validation. In this role, the incumbent will also be encouraged to develop their own ideas and contribute these to the broader group. They are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the entire organization to execute on various research programs. This role offers the opportunity to build industry-leading workflows that generate transformative proteomic insights supporting both foundational research and translational medicine.

Responsibilities :

Interact and collaborate with various discovery technologies functional teams to develop and implement high content and high throughput proteomic platforms

Design and execute studies using protein platforms like Olink, Somalogic, Milliplex, Quanterix, etc for biomarker discovery and mechanistic investigations

Develop scalable workflows for multiplex protein profiling across diverse sample types (plasma, serum, CSF, tissue lysates)

Stay current on cutting edge technologies and work collaboratively with proteomics team to validate and implement new proteomics platform as needed

Install, maintain, operate, and optimize platform instrumentation while ensuring peak performance and data quality

Innovate sample preparation protocols tailored to platform-specific chemistry and biological matrix requirements

Lead data analysis initiatives using advanced statistical methods, platform-specific tools, and machine learning approaches

Drive cross-functional collaboration with cell biology, immunology, computational biology, and clinical research teams

Generate actionable insights through comprehensive technical reporting and data visualization

Champion scientific excellence by staying at the forefront of proteomics technology advances and ultra-sensitive detection methods

Maintain rigorous standards for laboratory safety, regulatory compliance, and data integrity

Establish protocol QC methods and standards to ensure quality data and analyses from a variety of high throughput, high content genomic, transcriptomic, and proteomic platforms

Responsible for establishing and updating lab SOPs and training lab scientists as needed

Work with the entire molecular characterization team to ensure all instrumentation is properly maintained and calibrated

Proper documentation and archiving of data and analyses

Basic Requirements :

Master's degree (with 2-3 years’ experience) or Bachelor's degree (with 5+ years’) in Biochemistry, Proteomics, Immunology, Cell Biology, or related field

Hands-on expertise with Olink OR Somalogic platforms, including end-to-end study management from design through analysis is strongly preferred

Broad experience with multiple protein analysis platforms, including assay design and development

Experience with high content, high throughput laboratory workflows with emphasis on quality and efficiency

Demonstrated experience in working collaboratively across various scientific disciplines to meet project goals and timelines

Proven track record in interpreting complex biological data and translating findings into actionable research directions

Exceptional analytical and problem-solving capabilities with meticulous attention to experimental detail

Additional Preferences :

Proficiency in R or Python for large scale omics data analysis and visualization

Hands-on experience and thorough understanding of the mass spectrometry-based proteomic workflows

Demonstrated experience developing and validating complementary immunoassays (ELISA, MSD, Jess systems)

Expertise in pathway analysis and network biology approaches for systems-level insights

Knowledge of spatial proteomics methods and advanced tissue imaging techniques

Machine learning experience for biomarker signature development and validation

Strong publication record in peer-reviewed journals featuring high-plex proteomics applications

Experience with clinical sample management and biobanking best practices

Additional Information :

Physical Demands / Travel :

The physical demands of this job are consistent with a lab environment. Travel

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment :

This position’s work environment is in a laboratory environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

• To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and / or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include : Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$84,000 - $179,300

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and / or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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