Research Scientist in CRISPR Genomics, Engreitz Lab (2 YearFixed Term)

The Laboratory of Jesse Engreitz

(Dept of Genetics, BASE Initiative) is seeking a Research Scientist

in CRISPR Genomics (Life Science Research Professional 3) to lead

large-scale data production projects to understand the genetic

basis of heart diseases. The Engreitz Laboatory is located in the

Biomedical Innovations Building on the main campus at Stanford

University and is a member of the BASE Initiative in the Betty

Irene Moore Children’s Heart

Center.

Project

overview : DNA regulatory elements in the human genome, which harbor

thousands of genetic risk variants for common and rare heart

diseases and could reveal targets for therapeutics that aim to

precisely tune cellular functions — if only we could map the

complex regulatory wiring that connects 2 million regulatory

elements with 21,000 genes, and genes with thousands of pathways

across the diverse cell types in the human body. We have recently

developed new approaches that could enable mapping this regulatory

wiring at massive scale (see Fulco et al. Science 2016, Fulco et

al. Nat Genet 2019, Nasser et al. Nature 2021, Gschwind et al.

bioRxiv 2023), and applied these and other approaches to understand

the genetic basis of complex diseases (e.g., Schnitzler et al.

Nature 2024). We aim to expand these studies to systematically map

the functions of variants, enhancers, and genes in many cell types

from the heart and vasculature. These studies will ultimately help

to uncover biological mechanisms of congenital heart defects,

coronary artery disease, and other heart diseases to help to guide

diagnosis and therapeutic development. For information and recent

work, see

https : / / www.engreitzlab.org and

https : / / med.stanford.edu / base.html .

We

are looking for a creative and passionate Research Scientist

(PhD-level) to lead the next phase of our efforts to systematically

perturb the genome to understand genome function and phenotype. The

ideal candidate would lead independent projects, design and

supervise large-scale CRISPR data generation projects, manage

collaborations between the Engreitz Lab and NIH-led consortia, and

play a leading role in writing publications and grants. The

Engreitz Lab provides a dynamic, interdisciplinary workplace with

unique access to cutting edge technologies and scientific thought,

with the potential for widespread recognition of scientific

contributions. We value a diversity of values, backgrounds, and

approaches to solving

problems.

The

candidate for this position should have hands-on experience in

• cellular genomics, molecular biology, and technology development;

experience with quantitative data analysis and collaborating with

interdisciplinary teams; curiosity in research and creativity in

experience building or managing teams; outstanding verbal and

written communication abilities; ability to adapt to and

and have a passion for science and sense of urgency to find new

medicines to benefit

patients.

In

addition to submitting your application via the Stanford web

portal, please email your CV and cover letter directly to Prof.

Jesse Engreitz

( engreitz@stanford.edu ).

This is a 2-Year

Fixed-Term position, with extension

possible.

Duties

include : Make

fundamental discoveries about gene regulation and the genetics of

cardiovascular

disease

T ogether with

PI and other lab members, design and execute scientific projects

Collect comprehensive

perturbation datasets to inform genome function and enable training

predictive

models

D evelop and

apply strategies to study enhancers and genes in human cells and

mouse models

E valuate

and recommend new emerging technologies, approaches, and

problems

Supervise,

train, and collaborate with other lab members in experimental

techniques, scientific design, and other

skills

Design and lead

independent

projects

Collaborate

with a team of experimentalists and computational

biologists

Create

scientifically rigorous visualizations, communications, and

presentations of

results

Contribute to

generation of protocols, publications, and intellectual

property

assigned.

Grade : FTE :

100%

DESIRED

QUALIFICATIONS : Ph.D.

in Genetics, Biology, Biochemistry, Biophysics, Bioengineering,

Developmental Biology, or related life science field is preferred.

Highly motivated candidates of all levels are encouraged to

apply.

Expert in

genomics, molecular biology, assay development, and high-throughput

data generation

Experience with

quantitative data

analysis

Experience

with CRISPR targeting ES / iPS cells and / or single-cell technologies

a plus

Experience in

multidisciplinary collaborations, management, and / or

supervision

Curiosity

in research and creativity in

problem-solving

great team member with strong interpersonal and collaboration

skills

Outstanding

verbal and written communication

abilities

Ability to

adapt to and effectively manage changes in a fast paced and dynamic

environment

A passion

for science and sense of urgency to find new medicines to benefit

patients

EDUCATION

& EXPERIENCE

(REQUIRED) : Bachelor's

degree in related scientific field and four years of relevant work

experience; or Master’s degree in a related scientific field and

two years relevant experience; or PhD in related science

field.

KNOWLEDGE,

SKILLS AND ABILITIES

(REQUIRED) : Bachelor's

understanding of scientific

principles.

Expert

level knowledge and skills in field of science related to research

project.

General

computer skills and experience with databases and scientific

applications

Strong

analytical skills and excellent judgment.

Ability to work under

deadlines with general guidance is essential.

Excellent

organizational skills and demonstrated ability to complete detailed

work

accurately.

Developing

project management

skills.

CERTIFICATIONS

LICENSES : None.

PHYSICAL

REQUIREMENTS

Frequently

stand, walk, twist, bend, stoop, squat, grasp lightly, use fine

manipulation, grasp forcefully, perform desk-based computer tasks,

use telephone, write by hand, lift, carry, push and pull objects

weighing over 40 pounds.

Occasionally sit,

kneel, crawl, reach and work above shoulders, sort and file

paperwork or parts.

Rarely climb, scrub,

sweep, mop, chop and mix or operate hand and foot controls.

Must have correctible

vision to perform duties of the

job.

Ability to bend,

squat, kneel, stand, reach above shoulder level, and move on hard

surfaces for up to eight

hours.

Ability to lift

heavy objects weighing up to 50

pounds.

Position may

require repetitive

motion.

will provide reasonable accommodation to any employee with a

disability who requires accommodation to perform the essential

functions of his or her

job.

WORKING

CONDITIONS : May

require working in close proximity to blood borne

pathogens.

May require

work in an environment where animals are used for teaching and

research.

Position may

at times require the employee to work with or be in areas where

hazardous materials and / or infectious diseases are present.

Employee must perform

tasks that require the use of personal protective equipment, such

as safety glasses and shoes, protective clothing and gloves, and

possibly a respirator.

May require extended

or unusual work hours based on research requirements and business

needs.

WORK

STANDARDS (from

JDL) : Interpersonal

Skills : Demonstrates the ability to work well with Stanford

colleagues and clients and with external

organizations.

Promote

Culture of Safety : Demonstrates commitment to personal

uses and promotes safe behaviors based on training and lessons

learned.

Subject to

and expected to comply with all applicable University policies and

procedures, including but not limited to the personnel policies and

other policies found in the University's Administrative Guide,

http : / / adminguide.stanford.edu .

The

expected pay range for this position is $93,062 to $111,670 per

annum. Stanford University provides pay ranges representing its

good faith estimate of what the university reasonably expects to

pay for a position. The pay offered to a selected candidate will be

determined based on factors such as (but not limited to) the scope

and responsibilities of the position, the qualifications of the

selected candidate, departmental budget availability, internal

equity, geographic location and external market pay for comparable

jobs.

At

Stanford University, base pay represents only one aspect of the

comprehensive rewards package. The Cardinal at Work website

( https : / / cardinalatwork.stanford.edu / benefits-rewards )

provides detailed information on Stanford’s extensive range of

benefits and rewards offered to employees. Specifics about the

rewards package for this position may be discussed during the

hiring

process.

The

job duties listed are typical examples of work performed by

positions in this job classification and are not designed to

contain or be interpreted as a comprehensive inventory of all

duties, tasks, and responsibilities. Specific duties and

responsibilities may vary depending on department or program needs

without changing the general nature and scope of the job or level

of responsibility. Employees may also perform other duties as

assigned.

Consistent with its

obligations under the law, the University will provide reasonable

accommodations to applicants and employees with disabilities.

Applicants requiring a reasonable accommodation for any part of the

application or hiring process should contact Stanford University

Human Resources at stanfordelr@stanford.edu. For all other

inquiries, please submit a contact

form .

Stanford

is an equal employment opportunity and affirmative action employer.

All qualified applicants will receive consideration for employment

without regard to race, color, religion, sex, sexual orientation,

gender identity, national origin, disability, protected veteran

status, or any other characteristic protected by

law.