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Sr. Principal Scientist / Associate Director - Antibody Engineering
ZipRecruiterSan Diego, CA, United States1 day ago
Job type
- Full-time
Job descriptionMS / PhD in Biochemistry, Chemistry, or related field with 7+ years biopharma experience. Deep knowledge of protein structure, interactions, and physicochemical properties. Proven people leadership and experience managing scientists. Track record leading cross-functional programs from target validation through optimization to candidate nomination. Advanced understanding of multiple antibody formats (mAbs, bi / multispecifics, scFv, sdAbs, etc.). Extensive hands-on experience in antibody / protein engineering (humanization, liability removal, optimization). Familiarity with developability assessments (solubility, stability, manufacturability) and using them to guide design. Comfort with in-silico tools / programming / databases; exposure to ML-aided discovery a plus. Experience with plate-based assay development & high-throughput workflows. Engineering of small proteins / enzymes. Ability to synthesize structural / biophysical data (epitope mapping, kinetics, physicochemical profiling) for decisions.
Overview
Sr. Principal Scientist / Associate Director – Antibody Engineering
Location : San Diego, CA
Employment Type : Full-time
Hiring Company : BioPhase (on behalf of our client)
Pay : $170,000–$190,000 base + bonus; stock options
Hours : Monday–Friday, full-time (no overtime)
Responsibilities
- Serve as subject-matter expert for protein / antibody engineering, formatting, and structure–function hypotheses.
- Lead, mentor, and develop protein engineering scientists; provide technical oversight.
- Act as project lead to deliver milestones across discovery programs.
- Collaborate with biology, computational, and development teams to progress hits into developable candidates.
- Design / build antibody & protein combinatorial libraries; plan and run engineering campaigns.
- Drive continuous improvement of lab workflows and data practices.
- Oversee curation / aggregation of experimental & in-silico data to inform predictive models.
- Contribute to platform / technology strategy with scientific leadership.
Qualifications
Benefits
Comprehensive package including medical, dental, vision, life & insurance; 401(k) with match; PTO; parental leave; flexible schedule; relocation assistance (if applicable); year-end shutdown. Apply today and help us bring transformative biologics to patients!
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Sr Director Engineering • San Diego, CA, United States
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