Medical Affairs Operations, Business Project and Operations (BPO) Manager

Business Project And Operations Manager

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients.

argenx is a biotechnology company committed to developing innovative treatments for diseases with high unmet needs. This role plays a pivotal part in shaping and evolving the US Medical Affairs & Evidence Generation (USMAEG) operations while stewarding the department's budget planning and tracking. The Business Project And Operations (BPO) manager will lead organizational transformation and cross-functional strategic projects, and will own end-to-end financial management : budget planning, forecasting and tracking; vendor contracting and Statement Of Work (SOW) development; and procure-to-pay (P2P) activitiesincluding PO and invoice processing and issue resolutionto ensure timely delivery, compliance, and value for USMAEG initiatives.

Key Responsibilities

Finance & Vendor Operations

• Lead the annual operating plan (AOP) and ongoing re-forecast cycles for the USMAEG portfolio, including launch scenario modeling and alignment with leadership and Finance.
• Establish molecule- and indication-level budget trackers; monitor burn rates, identify variances, and drive mitigation actions with Finance.
• Own monthly / quarterly forecasting and prepare accruals in conjunction with Finance partners.
• Manage end-to-end P2P for USMAEG internal stakeholders : vendor onboarding, requisitions, PO creation / amendment, and invoice processing to policy and cycle-time targets.
• Develop, negotiate, and execute SOWs and change orders with vendors; define scope, deliverables, acceptance criteria, and milestone-based payment schedules in partnership with Legal and Procurement.
• Build dashboards and reports (e.g., Excel, Power BI) that provide real-time visibility into budget consumption, forecast accuracy, and vendor performance.

Strategic Project Management & Transformation

Cross-Functional Collaboration

Skills & Competencies

Education & Experience

At argenx, all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer.