Senior Director, Translational Biomarkers

Senior Director, Translational Biomarkers

Job Category : Research

Requisition Number : SENIO001881

Posted : September 14, 2025

Full-Time

Hybrid

Locations

Headquarters, 9704 Medical Center Dr, Rockville, MD 20850, USA

MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

We are seeking a highly innovative and motivated scientist to join the Research Department as a Senior Director, Translational Biomarkers. This individual will evolve and lead the Translational Biomarkers function that is responsible for defining and implementing biomarker strategies to inform translational oncology objectives for our ADC and immuno-oncology pipeline. Key areas of focus will include defining optimal target populations / patient segments, predictive efficacy and safety biomarkers, PK / PD relationships, mechanisms of drug resistance, and supportive evidence for combination strategies. This role will require cross-functional collaboration with pre-clinical and clinical functions and data management, as well as with all Translational Medicine functions including translational bioinformatics, pathology, flow cytometry, and toxicology.

Responsibilities

Develop and lead a Translational Biomarkers function within the Translational Medicine organization whose principal remit is to define and implement cutting-edge translational approaches that directly inform both clinical and preclinical development

Work cross-functionally within Translational Medicine, as well as with preclinical and clinical teams, to define data-driven, rational translational strategies with a clear link to development impact

Evolve knowledge of, and capabilities relating to, advanced translational technologies such as spatial -omics and multimodal data analysis designed to elucidate novel insights that inform translational objectives

Contribute to strategies, planning, and implementation for CDx development where indicated

Contribute to development of streamlined operational workflows to ensure efficient translational data handling, including but not limited to data import, QC processes, method development and standardization, and criteria for internal / external presentation

Participate in development of SOPs for translational data analysis that incorporate the use of both internal and external data sources

Participate in business development activities, including establishing and maintaining good collaborative alliance / academic relations

Participate in and serve in a leadership role for company-wide scientific initiatives

Promote external visibility through presentations at scientific meetings and through scientific publications

Education and Experience

MD or PhD in molecular biology or related field

Minimum of 12 years of related experience in industry / academia with focus on oncology drug development

A minimum of four (4) years of experience supervising scientific employees

Knowledge, Skills and Abilities

Deep knowledge base in tumor biology and applications to oncology drug development with demonstrable track record in successfully developing, applying and implementing translational biomarker strategies with development impact

Substantial experience designing and implementing data analysis plans in collaboration with data scientists and bioinformaticians

Broad and thorough understanding of drug development and clinical trial methodology

Ability to develop innovative analytic approaches to complex problems, including the ability to integrate knowledge of biological underpinnings of tumor biology, drug mechanism of action, and complex multimodal datasets to elucidate critical findings

Passionate about and experienced in working in a cross-functional and collaborative environment and experienced in influencing across the matrix

Self-motivated, detailed oriented, and able to distill complex issues and clearly articulate innovative solutions in a team environment

Excellent scientific communication skills, verbally and in writing, in informal 1-1 settings, team meetings, and formal seminars; effective communication is essential and includes presentations at cross-functional teams, internal review committees, external conferences, collaborators, and partners in addition to writing reports and collaborative scientific publications

Demonstrated learning agility, adaptability, collaborative skills, strong influencing skills and delivering results through teamwork

Strong desire to contribute to our mission of translating basic science and expertise into meaningful, long-lasting benefit for patients

Recognized as an expert internally and / or externally in the Translational Medicine arena

Demonstrates leadership and effective management skills

Supervisory Responsibilities

Associate Director, Translational Biomarkers

Additional Information

The annual rate of pay for this position ranges from $229,600 – $350,000. For non-exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company's discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company's benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.

The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate's experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company\'s sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law.

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email info@macrogenics.com or call (301) 354-3566 and / or 711 for TTD / TTY service.

Equal Opportunity Employer / Veterans / Disabled

We do not accept non-solicited resumes or candidate submittals from search / recruiting agencies.

Additional Sections

Equal Opportunity Employer

This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

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