Scientist

Job Title : Scientist

Length of Contract : 1 year (could be extended)

Location / Site : Worcester, MA, 01604, 100% On-site

Interviews - 2 rounds

30-minute teams call then a 1 hour virtual with video

What are the top 3-5 skills, experience or education required for this position :

1.Perform separation assays such as HPLC / UPLC chromatography

2.Perform fractionation using AKTA

3.Perform LC-MS experiments on intact protein

4.Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization

5. Excellent written communication, oral communication, organization, and multitasking skills

Description :

We are searching for a highly motivated Scientist to join our Analytical Development team at Client's Bioresearch Center in Worcester, MA. Our team is responsible for the development, qualification, and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages.

As a Scientist, you will be a part of the Analytical Characterization Group (ACG) within the Analytical Development Department. ACG focuses on providing routine, investigative, and in-depth characterization analyses of Client's biologics to support product and process development for early-phase, late-phase, and commercial programs using liquid chromatography mass spectrometry (LC-MS), spectroscopy and various other biophysical assays.

The successful candidate will contribute to the development and performance of analytical assays and will contribute to the continuous improvement and innovation within ACG and the Analytical Development Department.

Key Responsibilities :

• Perform mass spectrometry analyses (i.e., intact / reduced mass analysis by LC-MS and peptide mapping by LC-MS) of Client's biologics to provide sequence verification and post-translational modification profiles.
• Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA
• Perform biophysical methods (e.g., DSC) of Client's biologics to support characterization studies.
• Design and execute experiments for method development and / or investigations.
• Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry.
• Generate and communicate precise, reliable, and reproducible data in a timely manner.
• Organize and document experiments and results in an electronic laboratory notebook.
• Draft protocols, method development reports, and technical characterization reports.
• Maintain lab equipment.

Qualifications :