Scientist, In Vitro Models

Scientist, In Vitro Models

Were seeking a scientist to design, build, and validate our human in a dish platform that ensures translational relevance of our preclinical development pipeline. This includes establishing and optimizing in vitro human models such as patient-derived samples, tumor organoids, 3D cell models, organs-on-chip to debug and refine our molecular programs in physiologically relevant contexts. Youll develop immune-competent model systems to mimic the tumor microenvironment and immune interactions within healthy tissues. To support this work, youll build functional multi-omics workflows to profile these disease models using bulk and single-cell genomics technologies. Youll characterize synthetic genetic components and their combinations in the context of these models to anticipate their function in patients. This role requires long-term, strategic thinking to optimize the scale-up of cell culture operations with the goal of creating a pipeline of well-validated, characterized, and qualified human cell models for high-throughput functional genomics and drug discovery studies.

Primary Responsibilities

• Develop advanced in vitro human models of healthy and diseased primary cells, tissues, and organs to serve as a translationally relevant testing and validation platform
• Scale up culture of in vitro models to support high-throughput testing workflows
• Design assays for model characterization and to establish translational relevance
• Collaborate with our Synthetic Biology and Computational Biology teams to develop workflows for comprehensive high-throughput testing of multiple synthetic genetic components, their combinations, and therapeutic candidates
• Implement multi-modal bulk and single-cell assays as an integral part of testing workflows.
• Optimize and establish standard operating procedures for patient-derived tissue processing and dissociation
• Plan and manage complex projects including interfacing with clinical partners for sample acquisition and sequencing service providers
• Liaise with CROs, plan and oversee technology transfer and study execution at contract organizations, as needed
• Maintain detailed, well-organized documentation of experiments and data

Required Skills & Qualifications

At Pattern Bio, we design biological circuits at the intersection of synthetic biology and AI for cell-specific targeting of cancer tissue. By integrating data-driven design into every stepfrom DNA constructs to AAV-based delivery systemswe are building precise, rationally engineered, curative therapies. Our cohesive and driven team in South San Francisco is dedicated to curing cancer and saving lives.

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