PK/PD Modeling / Pharmacometrics LeadMercor • Newport News, Virginia, US
No longer accepting applications
PK / PD Modeling / Pharmacometrics Lead
Mercor • Newport News, Virginia, US
1 day ago
Job type
- Part-time
- Remote
Job descriptionWho we’re looking for Deep hands-on experience in PK, PD, exposure–response modeling , and ideally population PK or QSP . - Expert at model fitting, sensitivity analysis, and identifying non-plausible parameter spaces. - Can evaluate the validity of dose–exposure predictions and detect high-risk extrapolations. - Comfortable designing model evaluation rubrics that distinguish between acceptable vs. non-credible outputs. - Able to articulate how quantitative checks should complement narrative decision logic. Nice-to-have : Experience supporting translational or clinical pharmacology leads in dose justification. - Familiarity with integrating nonclinical PK / PD data (2-species GLP → human FIH extrapolation). ### Experience level ~8–12 years of quantitative pharmacology experience in pharma, CROs, or modeling consultancies . - Strong portfolio in population PK / PD exposure–response , and parameter estimation using NONMEM, Monolix, or equivalent tools. - Demonstrated ability to interpret model results for decision-making, not just fit data. - Can create fit-for-purpose models and critique model structures or assumptions under uncertainty. ### Expectations Design and refine micro-evaluations for PK / PD performance (curve fits, parameter checks, error taxonomies). - Encode quantitative sanity checks into model rubrics for automated evaluation. - Define failure conditions (e.g., unsafe extrapolation, poor coverage curves, invalid assumptions). Inputs we give : PK / PD datasets, tox summaries, and performance prompts (e.g., “fit exposure–response curves, interpret safety margins”). - Example model outputs from automated systems. Expected outputs : Quantitative Rubrics : clear thresholds for acceptable parameter fits, coverage curve quality, and model integrity checks. - Golden Fit Examples : representative “ideal” PK / PD model outputs and visualizations for calibration. - Error Taxonomy : structured list of typical modeling or fitting errors, with root-cause annotations. - Meta-Layer Commentary : short note per rubric capturing how expert modelers recognize implausible or unsafe fits beyond numeric error values. ### Engagement Model & Compensation Contract / part-time , remote, outcome-based deliverables.
This person complements the client’s “Translational / Clinical Pharmacology Decision-Maker” team by grounding dose selection and exposure–response analysis in
- quantitative structure and parameter plausibility
###
Create a job alert for this search
Modeling • Newport News, Virginia, US
Related jobs
LocumJobsOnline is working with Medicus Healthcare Solutions to find a qualified Endocrinology MD in Virginia!.Medicus has partnered with an established clinic in northern Virginia that has an oppo...Show more
Neurology – Independent Practice Track (MedCBO Supported).MedCBO is a Colorado-based healthcare business infrastructure company that empowers independent physician groups across the United States t...Show more
Job Description & Requirements.Medical Director, Pediatric Cardiac Critical Care Unit.StartDate : ASAP Pay Rate : $350000.
Children's Specialty Group (CSG), a Physician-Owned Private Practice, See...Show more
Thank you for considering a career at Bon Secours!.Days (United States of America).Monday - Friday, 8 : 00 AM - 4 : 30 PM.
Primary Function / General Purpose of Position.Employee demonstrates competence i...Show more
Deep expertise in retail domain testing (retail operations, supply chain, digital or merchandizing).Hands-on experience with functional testing for retail systems (e.
Proficiency in test management ...Show more
LocumJobsNetwork is working with Medicus Healthcare Solutions to find a qualified Endocrinology MD in Virginia!.Medicus has partnered with an established clinic in northern Virginia that has an opp...Show more
One Howmet Drive, Hampton, VA, 23661, US.Remote Work Schedule Availability?.This position entails access to export-controlled items and employment offers are conditioned upon an applicant's ability...Show more
Kempsville Center for Behavioral Health.Partial Hospitalization treatment for children and teens exhibiting behavioral and / or mental health concerns.
Our programs are designed to treat your child or...Show more
Looking for a Board Certified Pathologist to serve as Senior Medical Director of our well established, hospital employed, general pathology practice.
Cytopathology fellowship is preferred but not re...Show more
Specialty : Cardiology : Non-invasive Cardiology.Employment Type : Not Specified.Cardiology Non-Invasive Opportunity.Bon Secours Cardiovascular Specialists is currently seeking to hire a fulltime Non...Show more
Indexes scanned documents through point-of-service (POS) workflow and then reviews committed patient care documentation for completeness and accuracy.
Maintains the integrity of the electronic healt...Show more
Outstanding Urgent Care opportunity.Requires board certification in pediatrics as well as acute care or pediatric urgent care experience.
Provide treatment for illness, disease and injury like flu, ...Show more
Looking for a new Med Tech job? My name is Leah and I'm a healthcare recruiter, I'm here to help!.I have a Cytogenetics Med Tech role available near Chesapeake, Virginia!.Full, comprehensive benefi...Show more LocumJobsNetwork is working with Weatherby Healthcare to find a qualified Physical Medicine MD in Williamsburg, Virginia, 23188!.
Interested? Give Weatherby a call today and speak with one of our sp...Show more Job Description & Requirements.Pediatric Associate Medical Director, Inpatient Mental Health Program.Enjoy a leadership role in an innovative pediatric behavioral health program.Children's Spec...Show more Kempsville Center for Behavioral Health.Partial Hospitalization treatment for children and teens exhibiting behavioral and / or mental health concerns.
Our programs are designed to treat your child or...Show more 
Discover Your Impact in Recovery : Join Our Inpatient Physical Therapy Team in Norfolk, Virginia! Imagine a workday where your expertise empowers a patient to take their first steps after surgery, r...Show more A healthcare business infrastructure company is seeking a Nephrologist to develop innovative healthcare solutions and establish a new physician group.
Responsibilities include providing quality pati...Show more
Locum Physician (MD / DO) - Endocrinology in Virginia
LocumJobsOnline • Norfolk, US
Full-time
Last updated: 30+ days ago • Promoted
Neurology – Independent Practice Track (MedCBO Supported)
MedCBO, Inc • Norfolk, VA, United States
Full-time
Last updated: 13 days ago • Promoted
Medical Director, Pediatric Cardiac Critical Care Unit
AMN Healthcare • NORFOLK, US
Full-time
Last updated: 30+ days ago • Promoted
Sr. Neuro Tech - Maryview Medical Center
Bon Secours • Portsmouth, VA, United States
Full-time
Last updated: 4 days ago • Promoted
QEA (retail domain)
Stellar Consulting Solutions, LLC • Chesapeake, VA, United States
Full-time
Last updated: 3 hours ago • Promoted • New!
Locum Physician (MD / DO) - Endocrinology in Virginia
LocumJobsNetwork • Chesapeake, US
Full-time
Last updated: 30+ days ago • Promoted
Senior CMM Programmer
Howmet • Hampton, VA, United States
Full-time
Last updated: 30+ days ago • Promoted
Licensed Clinical Lead (LCSW, LPC)
Universal Health Services, Inc. • Norfolk, VA, United States
Full-time
Last updated: 30+ days ago • Promoted
Senior Medical Director of Pathology in Ohio - $476k base salary + $200k student loan repayment +bonuses
Southern Ohio Medical Center • Portsmouth, US
Full-time
Last updated: 30+ days ago • Promoted
Physician - Non Invasive Cardiology - Bon Secours Maryview Medical Center
Bon Secours Mercy Health • Portsmouth, US
Full-time
Last updated: 30+ days ago • Promoted
HIMS Analyst I
Riverside Health System • Newport News, VA, United States
Full-time
Last updated: 20 days ago • Promoted
Pediatric - Critical Care Medicine Physician
Inspire Healthcare • Newport News, VA, United States
Full-time
Last updated: 30+ days ago • Promoted
Cytogenetics MT in Virginia
K.A. Recruiting • Chesapeake, VA, United States
Full-time +1
Last updated: 30+ days ago • Promoted
Locum Physician (MD / DO) - Physical Medicine in Williamsburg, VA
LocumJobsNetwork • Norfolk, US
Full-time
Last updated: 30+ days ago • Promoted
Pediatric Associate Medical Director, Inpatient Mental Health Program
AMN Healthcare • Norfolk, US
Full-time
Last updated: 30+ days ago • Promoted
Licensed Clinical Lead
Universal Health Services, Inc. • Norfolk, VA, United States
Full-time
Last updated: 22 days ago • Promoted
DPT / Inpatient / Outpatient Physical Therapist
MLee Healthcare Staffing and Recruiting, Inc • Norfolk, VA, United States
Full-time
Last updated: 30+ days ago • Promoted
Nephrologist - Independent Practice Leader (Hybrid / Remote)
MedCBO, Inc • Norfolk, VA, United States
Remote
Full-time
Last updated: 13 days ago • Promoted