Executive Director / Vice President, Medical Lead

Job Description

Job Description

About Us

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.

Position Overview

Crescent Biopharma is seeking a Medical Lead to provide clinical leadership for one or more programs from preclinical through clinical development. This individual will own the medical strategy, lead study design and execution, and serve as the clinical face of the program with investigators, partners, and internal teams. This is a hands-on role suited for someone who thrives in a dynamic startup environment.

Responsibilities

• Develop and implement the clinical development strategy and target product profile for assigned program(s).
• Lead the design, initiation, and execution of early-phase clinical studies, including protocol and investigator brochure development, endpoint selection, and dose-escalation strategies.
• Serve as the medical monitor of ongoing studies, ensuring subject safety, high-quality data collection, and adherence to GCP and regulatory standards.
• Interpret and communicate emerging data across internal and external stakeholders, contributing to clinical study reports, publications, and presentations.
• Contribute clinical content for regulatory submissions, including IND / CTA filings, amendments, and briefing documents; support interactions with health authorities.
• Partner closely with cross-functional colleagues in nonclinical, translational, clinical operations, regulatory, program management and CMC to align program objectives and milestones.
• Build and maintain relationships with key opinion leaders, clinical investigators, and partners to inform study design and program direction.

Education & Experience

What We Offer

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Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.

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We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.