Director, Clinical Operations

Jade Biosciences is focused on developing innovative, best‑in‑class therapies to address critical unmet needs in autoimmune diseases. Our lead candidate, JADE101, is designed to inhibit the cytokine APRIL (A Proliferation‑Inducing Ligand) and is being developed for the treatment of immunoglobulin A nephropathy (IgAN), a chronic kidney disease that can impair kidney function over time. JADE101 aims to reduce harmful IgA antibodies, lower proteinuria (a key marker of kidney damage), and preserve long‑term kidney function. A Phase 1 healthy‑volunteer study of JADE101 is ongoing, with interim, biomarker‑rich data expected in the first half of 2026. Jade’s pipeline also includes a second development candidate, JADE201, and an undisclosed antibody discovery program, JADE‑003, both currently in preclinical development. For more information, visit JadeBiosciences.com and follow us on LinkedIn.

Role Overview

The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross‑functional teams and collaborating with internal stakeholders and external vendors. This individual will manage trial budgets, vendor selection, and risk mitigation while contributing technical input to key clinical documents. This individual will also mentor staff, foster strong team and cross‑functional relationships, and nimbly adapt in our dynamic organization. With proven leadership, financial acumen, and problem‑solving skills, this individual will thrive in Jade’s dynamic environment and evolve to support broader corporate initiatives. This is an exciting opportunity to make significant contributions to Jade’s immunology pipeline, leading trials from first in human single site to global (APAC, LATAM, etc.) phase 3, as assigned.

Key Responsibilities

Performs role of Clinical Operations trial lead for assigned trials and leads cross‑functional Study Execution Teams

Develops and executes trial operational strategies and partners cross‑functionally to drive trial execution forward; provides strategic and technical recommendations to senior leadership

Directs the selection of CROs and other vendors (IxRS, Central Lab, ancillary / tech vendors), directs development of vendor Scopes of Work (SOW), scope changes, budgets, and vendor payments and partners with CROs and other vendors to deliver on study execution

Creates and tracks clinical trial budgets

Directs risk mitigation, escalation, and resolution activities both internally and with sites and vendors

Directs technical and strategic input into the development of clinical documents (protocols, monitoring plans, informed consent forms, investigator brochures, clinical study reports)

Builds relationships with clinical sites, vendors, and key stakeholders and maintains an understanding of the external landscape and adjusts plans accordingly

Represents Clinical Operations in cross‑functional activities and supports development and management of the Clinical Operations function

Mentors more junior team members such as Clinical Trial Associates

Effectively builds strong internal teams and cross‑functional relationships and demonstrates leadership and team building skills, along with success in proactive risk mitigation and problem solving

Flexible and creative in meeting the needs and challenges of a growing, dynamic company and demonstrates excellent problem‑solving abilities

Strong financial acumen with outstanding track record of building budgets and managing expenses to budget

Contributes to corporate activities, including preparation of materials for Executive Team and Board of Director meeting materials

Qualifications

Bachelors + 15 years of related experience, or Masters + 12 years of related experience

10+ years of clinical research experience, including 7+ years of trial management within a biopharmaceutical company; 5+ years within a small / startup company is a plus

Exceptional clinical trial management skills with a focus on strategic oversight of trial execution on time and on budget, study coordinator and / or site monitoring experience a plus

Extensive phase 1 through phase 3, global trial management experience

Immunology and / or rare disease trial management experience

Extensive experience selecting and managing vendors, including CROs, labs, IxRS, EDC, and ancillary technology / applications (e.g. eDiaries, eConsent, apps, etc)

Thorough knowledge and understanding of FDA and ICH Guidelines, GCP, medical terminology, and clinical trials

Detailed understanding of all aspects of clinical protocol design, implementation, IND / BLA / NDA submissions, and overall drug development

Experience managing, coaching, and mentoring personnel

Excellent communication, organizational, negotiation, and interpersonal skills with a strong reputation for collaboration

Position Location

This is a remote role; periodic travel to team and company events is required.

The anticipated salary range for candidates for this role is $210,000 - $235,000. The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography.

As part of the I-9 verification of authorization to work in the United States, Jade Bioscience participates in E-Verify. To learn more about E-Verify please review this poster.

Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

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