Computational Postdoctoral Fellow (Cryo-EM)

Berkeley Lab's ( LBNL ) Molecular Biophysics and Integrated Bioimaging Division ( MBIB ) has an opening for a Postdoctoral Fellow to develop computational methods and software for protein structure determination.

In this exciting role, you will develop new mathematical approaches and computational algorithms to investigate protein conformational states from cryo-electron microscopy (Cryo-EM) experiments, including single-particle imaging and cellular tomography. This work will involve research and development of new hybrid methods that combine deep generative modeling, traditional optimization-based methods, numerical linear algebra, and Fourier analysis.

The goals include writing a pipeline for automated atomic modeling of heterogeneous structures from cryo-EM data using Phenix model building tools and developing methods for dealing with incomplete data and structure completion. You will work with a data analysis team for image analysis and the Phenix team for model building aspects. This position will require implementation and testing of software on simulated and experimental data, organization of results for presentations to team members and to the scientific community and preparing results for publication in scientific journals.

This position has an anticipated start date of November 1, 2025.

What You Will Do :

• Develop and implement computational algorithms for structure determination using cryo-electron microscopy including :

Generative modeling of conformational heterogeneity in electron microscopy.

What is Required :

Desired Qualifications :

Notes :

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Berkeley Lab is a University of California employer. It is the policy of the University of California to undertake affirmative action and anti-discrimination efforts, consistent with its obligations as a Federal and State contractor.

Misconduct Disclosure Requirement : As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct, are currently being investigated for misconduct, left a position during an investigation for alleged misconduct, or have filed an appeal with a previous employer.