Research Scientist in CRISPR Genomics, Engreitz Lab (2 Year Fixed Term) (Stanford)

The Laboratory of Jesse Engreitz (Dept of Genetics, BASE Initiative) is seeking a Research Scientist in CRISPR Genomics (Life Science Research Professional 3) to lead large-scale data production projects to understand the genetic basis of heart diseases. The Engreitz Laboatory is located in the Biomedical Innovations Building on the main campus at Stanford University and is a member of the BASE Initiative in the Betty Irene Moore Childrens Heart Center.

Project overview : DNA regulatory elements in the human genome, which harbor thousands of genetic risk variants for common and rare heart diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes, and genes with thousands of pathways across the diverse cell types in the human body. We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale (see Fulco et al. Science 2016, Fulco et al. Nat Genet 2019, Nasser et al. Nature 2021, Gschwind et al. bioRxiv 2023), and applied these and other approaches to understand the genetic basis of complex diseases (e.g., Schnitzler et al. Nature 2024). We aim to expand these studies to systematically map the functions of variants, enhancers, and genes in many cell types from the heart and vasculature. These studies will ultimately help to uncover biological mechanisms of congenital heart defects, coronary artery disease, and other heart diseases to help to guide diagnosis and therapeutic development. For information and recent work, see

https : / / www.engreitzlab.org

and

https : / / med.stanford.edu / base.html

We are looking for a creative and passionate Research Scientist (PhD-level) to lead the next phase of our efforts to systematically perturb the genome to understand genome function and phenotype. The ideal candidate would lead independent projects, design and supervise large-scale CRISPR data generation projects, manage collaborations between the Engreitz Lab and NIH-led consortia, and play a leading role in writing publications and grants. The Engreitz Lab provides a dynamic, interdisciplinary workplace with unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions. We value a diversity of values, backgrounds, and approaches to solving problems.

The candidate for this position should have hands-on experience in cellular genomics, molecular biology, and technology development; experience with quantitative data analysis and collaborating with interdisciplinary teams; curiosity in research and creativity in problem-solving; strong interpersonal and collaboration skills; experience building or managing teams; outstanding verbal and written communication abilities; ability to adapt to and effectively manage changes in a fast paced and dynamic environment; and have a passion for science and sense of urgency to find new medicines to benefit patients.

In addition to submitting your application via the Stanford web portal, please email your CV and cover letter directly to Prof. Jesse Engreitz (

engreitz@stanford.edu

This is a 2-Year Fixed-Term position, with extension possible.

Duties include :

Make fundamental discoveries about gene regulation and the genetics of cardiovascular disease

ogether with PI and other lab members, design and execute scientific projects

Collect comprehensive perturbation datasets to inform genome function and enable training predictive models

evelop and apply strategies to study enhancers and genes in human cells and mouse models

valuate and recommend new emerging technologies, approaches, and problems

Supervise, train, and collaborate with other lab members in experimental techniques, scientific design, and other skills

Design and lead independent projects

Collaborate with a team of experimentalists and computational biologists

Create scientifically rigorous visualizations, communications, and presentations of results

Contribute to generation of protocols, publications, and intellectual property

• Other duties may also be assigned.

Grade : H

FTE : 100%

DESIRED QUALIFICATIONS :

Ph.D. in Genetics, Biology, Biochemistry, Biophysics, Bioengineering, Developmental Biology, or related life science field is preferred. Highly motivated candidates of all levels are encouraged to apply.

Expert in genomics, molecular biology, assay development, and high-throughput data generation

Experience with quantitative data analysis

Experience with CRISPR targeting ES / iPS cells and / or single-cell technologies a plus

Experience in multidisciplinary collaborations, management, and / or supervision

Curiosity in research and creativity in problem-solving

A great team member with strong interpersonal and collaboration skills

Outstanding verbal and written communication abilities

Ability to adapt to and effectively manage changes in a fast paced and dynamic environment

A passion for science and sense of urgency to find new medicines to benefit patients

EDUCATION & EXPERIENCE (REQUIRED) :

Bachelor's degree in related scientific field and four years of relevant work experience; or Masters degree in a related scientific field and two years relevant experience; or PhD in related science field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED) :

Comprehensive understanding of scientific principles.

Expert level knowledge and skills in field of science related to research project.

General computer skills and experience with databases and scientific applications

Strong analytical skills and excellent judgment.

Ability to work under deadlines with general guidance is essential.

Excellent organizational skills and demonstrated ability to complete detailed work accurately.

Developing project management skills.

CERTIFICATIONS & LICENSES :

None.

PHYSICAL REQUIREMENTS

Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.

Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.

Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.

Must have correctible vision to perform duties of the job.

Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.

Ability to lift heavy objects weighing up to 50 pounds.

Position may require repetitive motion.

WORKING CONDITIONS :

May require working in close proximity to blood borne pathogens.

May require work in an environment where animals are used for teaching and research.

Position may at times require the employee to work with or be in areas where hazardous materials and / or infectious diseases are present.

Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

May require extended or unusual work hours based on research requirements and business needs.

WORK STANDARDS (from JDL) :

Interpersonal Skills : Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.

Promote Culture of Safety : Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.

Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide,

http : / / adminguide.stanford.edu

The expected pay range for this position is $93,062 to $111,670 per annum. Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.