Contract : Senior Research Associate, Antibody Purification & Engineering

Contract : Senior Research Associate, Antibody Purification & Engineering

Bothell, Washington, United States

Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.

This lab-based role centers on molecular biology, antibody expression and purification, and yeast display. You will own and operationalize work with external partners (e.g., CROs) while helping to build these capabilities in-house. Success in this role requires excellent organization, clear communication, and enthusiasm for learning and applying new technologies in antibody engineering.

Responsibilities

• Design constructs and cloning plans (vector selection, signal peptides, Fc / format swaps, tags) for synthesis at CROs; review sequencing / QC and manage plasmid maps with version control (ELN / LIMS).
• Oversee transient mammalian expression systems (primarily Expi293 and ExpiCHO) and direct high-throughput to mid-scale protein purification strategies.
• Execute purifications using multiple resins (Protein A, Nickel, SEC) and formats (magnetic, gravity, FPLC); establish and manage QC testing (e.g., SDS-PAGE / CE-SDS, aSEC, endotoxin, BLI).
• Design and generate yeast display libraries; perform MACS- and FACS-based selections and troubleshoot enrichment workflows.
• Support binder deconvolution (NGS / Sanger sequencing) and downstream hit screening (reformatting, BLI, flow cytometry).
• Analyze and summarize data; interpret results to inform technology development and project decisions.
• Collaborate across biology, chemistry, pharmacology, and translational medicine; organize data for effective cross-team sharing.
• Maintain detailed, reproducible electronic lab notebooks; present findings to internal teams and contribute to project updates and strategy.
• Stay current on techniques for producing and characterizing protein therapeutics; contribute to team learning and best practices.

Qualifications

Knowledge and Skills

E / E / O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

WA State Contract Pay Transparency (Hourly Rate)

$65.66 - $79.14 USD

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