Biologist

Job Description

Job Description

Job description :

We are currently seeking a highly motivated and passionate scientist to join our team in Immunology Discovery based in Cambridge MA.

In this role, the candidate will collaborate with multiple cross-functional teams to advance portfolio projects, with a particular emphasis on supporting in vitro data generation.

Responsibilities include performing and adapting cell-based in vitro protocols in a timely manner across diverse cell systems, data analysis and effective communication of results, and collaboration across multiple teams.

The position offers a unique opportunity for a talented scientist to work in a dynamic, innovative, and multi-disciplinary environment to develop their career at the interface of basic research and early drug discovery.

The position requires ability to work independently, demonstrate excellent technical, written and oral communication skills and work very well in a collaborative team environment.

Human colon organoid culture, passaging, and plating for experiments to support the group

Perform cell-based assays using cell lines and mammalian primary cells

Test biologic and small molecules in cell-based assays for functional readouts including cell proliferation, cytokine release, and gene expression.

Perform advanced molecular and cellular biology techniques (including but not limited to FACS, ELISA, MSD, HTRF, qPCR)

Responsibilities may include processing animal tissue ex vivo and isolation of immune cells from human and animal tissue or blood

Work independently on the design, execution and interpretation of experimental results to validate hypotheses related to the project need

Maintain close communication with multiple groups to support human colon organoid cell needs

Implement and innovate new experimental protocols / techniques as needed

Analyze, interpret, document and report data consistently, concisely and rigorously, both to individual stakeholders and in group settings

Demonstrate scientific excellence through dedication to multiple projects in a fast-paced multi-disciplinary environment

Impact projects mostly through lab-based activities

Qualifica tions

Must have a bachelor's degree in Biological Science or related field with 2+ years of experience in biotech or pharma setting (industry experience)

Experience in in vitro cell culture (sterile techniques, handling challenging cell types) is required.

Experience with primary epithelial cells and human colon organoids is required.

Experience with immune cells including myeloid cells (monocytes macrophages or dendritic cells) is required.

Experience in immunoassays including multi-color flow cytometry and ELISA (or MSD, HTRF) is required.

Experience with gene expression analysis by qPCR is required

Experience with ex vivo animal tissue processing is a plus.

Ability to learn new skills and apply them in a fast-paced research environment.

Creativity, problem-solving, and attention to details.

Excellent oral and written communication and collaboration skills.

Ability to work independently as well as in a team.

Proven flexibility to deal with changing timelines and shifting work priorities.

Experience with in vitro assays with primary human immune cells (ie myeloid, PBMCs)

Experience with molecular and cellular analysis techniques including qPCR, MSD, ELISA, flow cytometry

Experience with cell-based assay development is a plus.

Benefits :

Healthcare Insurance : Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance : Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance : Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan : The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.

Technical Certification Bonus : Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.

Synectics is an equal opportunity employer.