Associate Medical Director, Clinical Development

The Position

The Associate Medical Director will report to Arrowhead's Medical Director and play a key role in advancing innovative RNA interference-based therapies to patients. This individual will work collaboratively with Arrowhead's scientific and clinical teams, guiding drug candidates from discovery through early-stage clinical development.

The initial focus will be on siRNA programs targeting metabolic, renal, neuro, and complement-mediated diseases. While experience in these areas is preferred, it is not required.

In this role, the Associate Medical Director will take hands-on responsibility for designing and managing translational studies and early-phase clinical trials, assessing the efficacy, safety, clinical pharmacology, and pharmacokinetics of product candidates across various disease areas. This is a unique opportunity to contribute to the development of cutting-edge therapeutics and make a meaningful impact on patient care.

This is a fulltime, onsite position based from Arrowhead's Corporate Headquarters in Pasadena, CA.

Responsibilities

• Support the design, development, execution and communication of translational and clinical studies across a wide variety of therapeutic areas;
• Act as a medical lead in a cross functional team that includes medical scientific, clinical, safety, program and regulatory staff
• Effectively communicate protocols and other relevant information with clinical site investigators and staff
• Interpret clinical trial data and communicate results clearly and accurately
• Act as medical monitor for clinical studies and provide clinical input to safety assessments
• Contribute to documents, including IRB submissions, protocols, CSRs, publications and regulatory submissions
• Identify key opinion leaders and participate in clinical advisory board meetings
• Make scientific presentations at advisory boards, key scientific meetings and external committee meetings
• Identify and evaluate medical need and clinical path for new applications of RNA interference for the treatment of disease
• Collaborate with scientific staff to drive new drug candidates through preclinical development
• Monitor and understand new developments in RNA interference in industry and academia
• Support in-licensing and out-licensing activities and partner relationships

Requirements

• MD or MD/ PhD combined with research experience
• Hands-on translational research experience within a pharmaceutical or biotechnology company or in an academic setting
• Demonstrated understanding of the drug development process and a strong desire to contribute to the development of meaningful therapeutics
• Knowledge of Good Clinical Practices, FDA regulations and guidelines and applicable regulatory requirements
• Ability to effectively evaluate outside expert advice
• Ability to clearly elucidate complex scientific and medical concepts via written and oral communication
• Working independently and effectively in a fast-paced, team-based environment
• Strong clinical/scientific/technical skills
• Strong interpersonal skills and the ability to communicate effectively with people in diverse and different settings
• Possesses sense of urgency; identifies challenges and problems and takes the initiative to identify solutions
• Project management skills and focus on delivery of results

Preferred:

• Fellowship training