Research Scientist II, Biologics Engineering & Conjugation

Band

Level 2

Job Description Summary

#LI-Onsite

Internal Job Title : Research Scientist II

Location : San Diego CA

This position will be located at San Diego CA site and will not have the ability

to be located remotely.

The Biologics Research Center (BRC) is seeking a highly motivated Research Scientist II with the skills and experience to contribute to advancing ADC drugs to patients in need. This is a great opportunity to join a group dedicated to protein antibody oligonucleotide / antibody drug conjugate discovery. The ideal candidate will possess a demonstrated expertise in protein sciences with an emphasis on protein purification process optimization and characterization. Responsibilities will include a range of activities related to protein purification and characterization of complex antibodies. The ideal candidate will be familiar in the design optimization and execution of multi-step purification analytical data interpretation troubleshooting and formulation of final product while maintaining a highly productive and collaborative culture.

Job Description

Key Responsibilities :

• Independently design purification methods understand biochemical concepts interpret data and troubleshooting.
• Participate on project teams to discover optimize and manufacture antibody-based biologics antibody-drug and / or oligonucleotide conjugates (ADCs / AOCs); offer technical advice at cross-functional team meetings; share technical expertise with other colleagues.
• Work effectively as a member of cross-functional teams to accomplish shared project goals.
• Special emphasis will be placed on automated antibody purification which will involve working with Cytiva AKTA (Pure / Avant) and Unicorn software and parallel purification using the Protein Maker.
• Mono and multi-specific antibody purification : preparation and packing of chromatography columns and conducting endotoxin free chromatography including operating preparative and analytical chromatography systems.
• Perform in-depth analytical characterization of molecules : endotoxin measurements protein quantitation assays analytical FPLC chromatography (anSEC)
• Coordinate the submission for supplementary biophysical characterization and interpret analytical results with area experts.
• Storing inventorying and ordering department supplies and chemicals and preparing chemical solutions according to department procedures specifications or supervisory instructions.
• Contemporaneous and accurate documentation of experiments in ELN and registration databases
• Contribute to patents publications and technical reports

Essential Requirements :

Desirable Requirements :

The salary for this position is expected to range between $73500 and $136500 per year.

The final salary offered is determined based on factors like but not limited to relevant skills and experience and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and depending on the level of the role eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health life and disability benefits a 401(k) with company contribution and match and a variety of other addition employees are eligible for a generous time off package including vacation personal days holidays and other leaves.

To learn more about the culture rewards and benefits we offer our people click here.

EEO Statement :

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment hiring training promotion or other employment practices for reasons of race color religion gender national origin age sexual orientation gender identity or expression marital or veteran status disability or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the application process or in order to perform the essential functions of a position please send an e-mail to call 1 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Range

$73500.00 - $136500.00

Skills Desired

Algorithms Algorithms Analytical Skill Analytical Thinking Chemical Biology Clinical Research Clinical Trials Collaboration Communication Skills Curiosity Data Data Analysis Design Of Experiments Detail-Oriented Diversity & Inclusion Drug Discovery Ethics Hypothesis Testing Immunology Laboratory Lifesciences Mammalian Cell Culture Medical Research Molecular Biology Organization 6 more

Key Skills

Laboratory Experience,Machine Learning,Python,AI,Bioinformatics,C / C++,R,Biochemistry,Research Experience,Natural Language Processing,Deep Learning,Molecular Biology

Employment Type : Full-Time

Experience : years

Vacancy : 1

Yearly Salary Salary : 73500 - 136500