Associate Scientist I

Position Title - Associate Scientist I

Duration - 1 year from start date

Location- 94080, South San Francisco, CA

Work shift (days / times) - Mon - Friday / standard working hours (flexible)

The Cell Line Development Group in South San Francisco, CA is seeking an Associate Scientist I to join a talented and collaborative team developing CHO cell lines for GMP applications. In this laboratory position the candidate will perform hands-on CHO cell line development and characterization studies in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. The work will encompass molecular, cellular, and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our cancer pipeline candidates.

Key Responsibilities :

• Perform CHO cell line development, including transfection, selection, single cell sub cloning, growth and productivity screening, cell banking and stability assessment of cell banks.
• Design and generate DNA vector constructs for protein including monoclonal antibodies and antibody-like molecules)
• Culture mammalian cells across multiple scales and formats, from 96-well plates up to shake flasks.
• Operate instruments like ViCell automated cell counter, Octet, Clone Select Imager, microscope, HPLC, ambr15, Beacon and flow cytometer. Share responsibility for equipment maintenance.
• Perform genetic characterization of cell banks using molecular techniques like DNA sequencing and PCR.
• Review DNA sequencing data (including NGS), Southern / Northern blots, quantitative PCR results.
• Author and review cell line development technical reports that meet expectations of regulatory agencies for all stages from IND to BLA.
• Present updates at cross-functional meetings and collaborate closely with cell culture, purification, analytical and formulation development colleagues to meet project timelines.
• Actively seek opportunities to optimize or enhance the cell line development workflow.
• May publish or present scientific findings in peer-reviewed journals, internal or external conferences or consortia.
• Display effective organization, verbal and written communication skills, and adherence to good documentation practices.

Qualifications

Basic :

Preferred :