Senior Research Investigator (Department of Neuroscience)

Senior Research Investigator (Department of Neuroscience)

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title

Senior Research Investigator (Department of Neuroscience)

Job Profile Title

Research Investigator, Senior

Job Description Summary

The Senior Research Investigator (SRI) will act in a leadership role, overseeing and designing advanced experiments. He / She / They will assist the Principal Investigator and play a leading role in developing a research project that uses human induced pluripotent stem cells (hiPSCs)-derived 2D and 3D models to study the impact of risk variants of schizophrenia on the molecular and cellular mechanisms underlying deficits in early neurodevelopment and synaptic properties. Results derived from this study potentially will help in devising novel therapeutics for schizophrenia.

The SRI will play a crucial role in all aspects of research products including development, implementation, and data analysis. In the development stage, the SRI will assess proposed projects by conducting feasibility studies to provide valuable input regarding efficiency, timeline, and study design. In the implementation stage, he / she will supervise and perform the projects. This includes overseeing workflow and productivity of personnel and providing training to them on specific methods as necessary. Finally, the SRI will be responsible for data analysis, preparation of manuscripts, liaising with external partners, and presenting research findings through various forums. The SRI must demonstrate the ability to analyze and present data in professional "publication ready" format and to be able to independently prepare manuscripts and grant writings for submission.

Job Description

Job Responsibilities

The successful applicant will have extensive experience in the fields of stem cell biology, molecular biology, iPSC culture, biochemistry, human genetics, neuroscience, epigenetics, and bioinformatics. To this end, we seek a candidate who will lead every aspect of the project.

The SRI will :

• Design and implement experiments under the supervision of Dr. Hongjun Song.
• Generate isogenic hiPSC lines using CRISPR / Cas9 with different genetic backgrounds parental lines editing different loci of target genes.
• Differentiate isogenic hiPSC lines into 2D cortical and hippocampal neurons and 3D cortical and hippocampal organoids.
• Analyze transcriptomic and epigenomic data at both the single and bulk-cell level.
• Perform immunostaining and neuronal electrophysiology (ephys) experiments for 2D and 3D cultures and analyze imaging and ephys data.
• Manage teams of undergraduate / graduate students and post-doctoral trainees

Position is contingent on continued funding.

Qualifications

Job Location - City, State

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$36,368.00 - $100,000.00 Annual Rate

Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.

Affirmative Action Statement

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements

Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits

To learn more, please visit : https : / / www.hr.upenn.edu / PennHR / benefits-pay

To apply, visit https : / / wd1.myworkdaysite.com / en-US / recruiting / upenn / careers-at-penn / job / Clinical-Research-Building 1st-Floor / Senior-Research-Investigator Department-of-Neuroscience-_JR00088428

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