Project Team LeadBoston

Project Team Lead

Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.

Position :

Manifold Bio is seeking an experienced drug discovery and development Project Team Leader (PTL) to lead cross-functional scientific teams to progress novel tissue-targeted therapeutic programs from early discovery to early clinical evaluation. The PTL will use their knowledge and experience of drug development, in combination with strategic guidance from company leaders, to define the integrated drug discovery and development strategies for 1-2 tissue-targeted therapeutic programs.

Responsibilities :

• Provides strategic and scientific leadership for cross-functional project teams focused on the development of tissue-targeted therapeutic molecules as they transition from early discovery (lead identification) into early clinical development.
• Develops clear work plan that maps out timing and resourcing requires to execute on critical path activities to progress novel lead tissue-targeted therapies from lead ID through early clinical testing, including candidate nomination, nonclinical PK and safety evaluation, CMC activities, regulatory submissions, and early clinical testing.
• Maintains team focus on efficient execution IND-enabling workplans. Works with project managers to track execution of critical path activities relative to target timelines and budget.
• Updates strategy based on emerging scientific data, changes in competitive landscape, and company strategic priorities; supports timely and clear project team decision-making that aligns with that strategy.
• Facilitates identification and resolution of issues / gaps; risks and risk-mitigation strategies. Prioritizes timely, resource-efficient solutions that are aligned with company priorities.
• Ensures cross-functional project team decisions are made in a timely manner and are aligned with company strategic priorities and latest scientific data.
• Advocates for the program with internal and external stakeholders; supports two-way communication between senior leadership and project team members. Ensures the opinions and perspectives of internal and external partners and stakeholders are heard and understood.
• Fosters a team culture of rigor, grit, accountability, and continuous improvement.

Position Requirements :

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.