Talent.com
Oncology Principal Investigator
Oncology Principal InvestigatorPlexus Partners • Anaheim, CA, US
No longer accepting applications
Oncology Principal Investigator

Oncology Principal Investigator

Plexus Partners • Anaheim, CA, US
30+ days ago
Job type
  • Full-time
Job description

Job Description

Oncologist / Principal Investigator - Clinical Research leadership


Location: Los Angeles, CA (relocation assistance provided)

Employment Type: Full-Time, On-Site

Salary: $700k-800k base salary, bonuses and incentives


Overview

We are representing an exceptional research-focused oncology organization seeking a Principal Investigator (PI) to oversee a highly experienced clinical team and drive breakthrough studies with biotech sponsors.


This is a full-time, research-only role, offering the opportunity to guide cutting-edge oncology trials in a fast-growing, data-driven clinical environment.


The position is ideal for an oncologist who wants to transition from purely clinical practice into a leadership role at the intersection of science, medicine, and industry, helping advance next-generation cancer therapies.


Key Responsibilities

  • Serve as the Principal Investigator for oncology trials across multiple modalities and sponsors.
  • Provide medical oversight, ensure patient safety, and maintain protocol compliance and data integrity.
  • Supervise and mentor sub-investigators, nurse practitioners, and clinical operations staff.
  • Collaborate closely with sponsors, CROs, and internal study teams to drive enrollment and site performance.
  • Support scientific and operational strategy, SOP refinement, and future site development.
  • Participate in investigator meetings, safety reviews, and regulatory inspections.


Ideal Candidate

  • MD or DO with board certification or eligibility in Hematology/Oncology (or related discipline).
  • 2+ years post-fellowship experience (early-career attendings encouraged to apply).
  • Demonstrated clinical excellence and the ability to manage oncology patients in a research setting.
  • Prior Sub-I or PI experience preferred but not required — full GCP training and mentorship provided.
  • Strong communication skills, collaborative mindset, and enthusiasm for research and innovation.
  • Must be committed to a full-time, on-site position.


Why This Opportunity

  • Exceptional Organization — culture of scientific rigor, integrity, and collaboration.
  • Exposure to Cutting-Edge Oncology Programs — work on next-generation therapeutic approaches.
  • Leadership Trajectory — opportunity to expand into multi-site or network-level leadership.
  • Competitive Compensation — highly attractive package with relocation and performance incentives.


This search is being managed exclusively by Plexus Partners.


Interested candidates can submit a CV or express interest in confidence to:


elliot@plexus-partners.com

Create a job alert for this search

Oncology Principal Investigator • Anaheim, CA, US

Similar jobs

Physician | Infectious Disease and Hospital Epidemiologist | Duarte, CA

HealthEcareers - ClientDuarte, CA, USA
Full-time

Physician | Infectious Disease and Hospital Epidemiologist | Duarte, CA.Department of Medicine | City of Hope National Medical Center | Duarte, CA.City of Hope Medical Group Seeks an Infectious Dis...Show more

 • Promoted

Clinical Research Coordinator

Pride HealthNewport Beach, CA, United States
Permanent

Pride Health is hiring a Clinical Research Coordinator RN! (Full time, ON-SITE).Manages complex clinical research trials, including industry-sponsored, government-funded, and investigator-initiated...Show more

 • Promoted

Physician Opportunity - Practice Ownership Opportunity in North Dakota

MDVIP, LLCNone, ND, US
Full-time

Are you a primary care physician searching for the practice of your dreams? .This is a rare chance to acquire an established, thriving MDVIP affiliated practice- built for the way you always envisi...Show more

 • Promoted

Assistant Investigator Associate

TradeJobsWorkforce90022 East Los Angeles, CA, US
Full-time

Take the next step in your career as our new Assistant Investigator Associate to adapt to shifting priorities and business needs, coordinate tasks to ensure deadlines are met, and maintain accurate...Show more

 • Promoted

Ophthalmologist | Fullerton, CA | Highly competitive Guaranteed Base + transparent track to partnership

NVISION Eye CentersFullerton, CA, US
Full-time

Guaranteed Base + Productivity Incentive + Partnership Track.Established, high-volume cataract and comprehensive ophthalmology practice.Strong OD and PCP referral network throughout North Orange an...Show more

 • Promoted

Primary Care Physician

Cross CountryNewport Beach, CA, US
Full-time

Join our Bakersfield, California Team!.Primary Care Physician – Full Time.MD or DO degree from an accredited medical school.Board Certified or Board Eligible in Internal Medicine or Family Practice...Show more

 • Promoted

Principal Regulatory Specialist

BioTalentOrange County, CA, United States
Full-time

Principal Regulatory Affairs Specialist (Hybrid – Orange County, CA).Principal Regulatory Affairs Specialist.Class III, catheter-based medical devices.This is a high-impact, hands-on role supportin...Show more

 • Promoted

Coronor

TradeJobsWorkForce92701 Santa Ana, CA, US
Full-time

Coronor Job Duties: Determines circumstances of death by directing work activities of staff physicians, technicians, and investigators.Determines cause of death by conducting inquests;...Show more

 • Promoted

Primary Care Physician

Cross Country Work Force SolutionsNewport Beach, CA, US
Full-time

Join our Bakersfield, California Team!.Primary Care Physician – Full Time.MD or DO degree from an accredited medical school.Board Certified or Board Eligible in Internal Medicine or Family Practice...Show more

 • Promoted

Pathologist - Downey

Southern California Permanente Medical GroupDowney, CA, US
Full-time

Southern California Permanente Medical Group (SCPMG) is a physician-led partnership with strong values that support a patient-centered and evidence-based approach to medicine.Provides our physician...Show more

 • Promoted

Associate Dean, Educational Partnerships

InsideHigherEdWalnut, California, United States
Full-time

Associate Dean, Educational Partnerships.Associate Dean, Educational Partnerships.Shift differential eligibility based on the current collective bargaining agreement.San Antonio College offers a co...Show more

 • Promoted

Dosimetrist - Fountain Valley Rad Oncology - FT Days

University of California - Irvine HealthFountain Valley, California, United States
Full-time

University of California, Irvine, and the only academic health system based in Orange County.UCI Health is comprised of its main campus, UCI Medical Center, a 459-bed, acute care hospital in in Ora...Show more

 • Promoted

Appeals M.D. - Gastroenterologist Required - Remote

UnitedHealth GroupCypress, California, United States
Remote
Full-time

At UnitedHealthcare, we're simplifying the health care experience, creating healthier communities and removing barriers to quality care.The work you do here impacts the lives of millions of people ...Show more

 • Promoted

Junior Investigator

TradeJobsWorkforce92711 Santa Ana, CA, US
Full-time

As a Junior Investigator, you will be responsible for assisting investigative teams and supporting case work, including: assist lead investigator in gathering information.Duties and responsibilitie...Show more

 • Promoted

Hematology/Oncology

The Permanente Medical Group, Inc.Anaheim, CA, United States
Full-time +1

Fulfilling the promise of medicine.The Permanente Medical Group, Inc.TPMG - Kaiser Permanente Northern California) is one of the largest medical groups in the nation with over 10,000 physicians, 21...Show more

 • Promoted

Epidemiologist

TradeJobsWorkForce90040 Commerce, CA, US
Full-time

Plan and direct studies of public health problems to find ways to prevent and treat them if they arise Collect and analyze data—through observations, interviews, and surveys, and by using samples o...Show more

 • Promoted

Surveillance Investigator

Allied UniversalOrange, California, United States
Full-time

US-CA-San Clemente | US-CA-Orange.Advance Your Career in Insurance Claims with Allied Universal Compliance and Investigation Services.Allied Universal Compliance and Investigation Services is the p...Show more

 • Promoted

Associate Chief Medical Officer, AHN

AltaMedMontebello, CA, United States
Full-time

Grow Healthy If you are as passionate about helping those in need as you are about growing your career, consider AltaMed.At AltaMed, your passion for helping others isn't just welcomed - it's nurtu...Show more