Sr. Downstream Processing Technician

Job Description

Job Description

Downstream Processing Technician

Job Description

The Downstream Processing Technician will play a pivotal role in supporting the manufacture of Commercial and Clinical Biologics. This position involves following Current Good Manufacturing Practices (cGMPs) and performing various functions related to downstream processes such as purification and filtration / HPLC. Key activities include propagation of mammalian cell culture, aseptic cell culture operations, execution of large-scale production bioreactors, and conducting large-scale filtration or centrifugation. The technician will also handle purification through large-scale chromatography.

Responsibilities

• Review all area documents.
• Manage the WNS.
• Assist in the manufacture of controls and calibrators and complete batch records following cGMPs.
• Perform in-process assays using equipment such as spectrophotometers, pH meters, and clinical analyzers.
• Weigh, transfer, and mix chemicals as required.
• Perform product filtrations.
• Clean and steam steel tanks (CIP) / (SIP).
• Prepare glassware and steel tanks for sterilization in autoclave and operate autoclave.
• Maintain lab equipment including pumps, pH meters, and flow meters.
• Keep department lead or manager updated on all issues.
• Monitor stocks of common lab supplies.
• Perform other job duties as required.
• Respond to emergency notifications.
• Work flexible hours and on weekends.

Pay-$32 / hr

Essential Skills

Additional Skills & Qualifications

Work Environment

The role requires working in cleanroom / aseptic suites with a rotating night shift schedule (6 : 15 pm-6 : 45 am) over a 12-hour shift pattern, working 7 days out of a 2-week period. A full gowning suit is required, including a bodysuit, gloves, hair & beard nets, face covers, and safety glasses. Ability to meet clean room gowning requirements, including wearing Tyvek, Nitrile, and / or Latex gloves, is essential. Candidates must be able to lift a minimum of 25 lbs independently and stand for 80% of the shift. This is a great opportunity to gain experience in large-scale biological and chemistry pharma operations, supporting the production of biologics used in pharmaceuticals for autoimmune diseases

Pay and Benefits

The pay range for this position is $32.20 - $32.20 / hr.

Eligibility requirements apply to some benefits and may depend on your job

classification and length of employment. Benefits are subject to change and may be

subject to specific elections, plan, or program terms. If eligible, the benefits

available for this temporary role may include the following :

Workplace Type

This is a fully onsite position in Saint Louis,MO.

Application Deadline

This position is anticipated to close on Oct 30, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.