NMR Spectroscopist / Specialist (CDMO / Pharma)

Job Description

Job Title : NMR Spectroscopist

Job Type : Full-time

Work Location : On-site Cranbury, NJ (with the possibility of assignment to South Plainfield, NJ).

Job Description :

We are seeking an experienced NMR Spectroscopist to join our team in the CDMO industry. The ideal candidate will be responsible for the maintenance and buildout of our NMR facility, troubleshooting NMR instrumentation, and performing structural elucidation of small molecule drug substances. This role also involves identifying and elucidating impurities and degradants, and effectively communicating NMR data for structural analysis. Strong teamwork and excellent communication skills are essential.

J-STAR Research, Inc. is a subsidiary of Porton that specializes in providing contract chemistry services to the biopharmaceutical and biotechnology industry. Our primary focus is resolving intricate chemistry problems relating to Active Pharmaceutical Ingredients and Intermediates in the preclinical and clinical development phases. We are adept in synthetic chemistry and process research services, which include Process Chemistry, Quality Control, Good Manufacturing Practice, Quality Assurance, Crystallization Research and Development, Solid Form and Polymorph Screening, Catalysis Screening and Enabling Technology, High Potent Compound Handling (HPAPI), Impurity Isolation and Structural Elucidation, and Preformulation and Formulation Research and Development.

At J-Star, there are 5 NMR systems including one 500 MHz H / C / N Cryoprobe as well as two 400 MHz Bruker systems with multiple-nuclear and variable temperature capabilities. We are hiring an NMR Spectroscopist to support project team decisions and improve the speedy delivery of API for our clients.

Responsibilities :

• Oversee the general maintenance and development of the NMR facility.
• Independently troubleshoot and resolve issues with NMR instrumentation.
• Perform structural elucidation of small molecule drug substances, intermediates, and starting materials.
• Identify and elucidate the structures of related impurities and degradants from API synthesis, fate and purge, and stress degradation studies.
• Provide clear oral and written explanations of NMR data for structural elucidation.
• Collaborate effectively with a team of chemists.

Requirements :

BS, MS, Ph.D. with 5+ years or MS with 10+ years of post-graduate industrial or academic experience in small molecule NMR data collection and interpretation.

Degree in Organic Chemistry, Physical Chemistry, Pharmaceutical Sciences, Physics, or a related field.

Experience troubleshooting NMR hardware and software (Bruker and Varian), including magnets, consoles, conventional and cryoprobes, autosamplers, and workstations (Windows and Linux).

Demonstrated ability to creatively apply NMR techniques to pharmaceutical problems.

Strong understanding and application of NMR theory for solving chemical structures and interactions of small molecules.

Experience using 1D (1H, 13C, 19F, 15N, etc.) and 2D (COSY, ROESY, HSQC, HMBC, TOCSY, etc.) multinuclear solution-state NMR techniques on high-field NMR instruments (300-500 MHz) equipped with conventional and cryoprobe technology.

Experience :

NMR Experience : 4 years (Required)

Pharmaceutical CDMO Industry Experience : 5 years (Preferred)

Relocation :

Must be able to relocate to Cranbury and South Plainfield, NJ before starting work (Required)

Work Location :

In-person