Research Associate Co-Op, Protein Biochemistry / Engineering

Overview

Keros Therapeutics is seeking a highly motivated and collaborative individual to join our protein biochemistry group within our Research Department. Our group exploits multidisciplinary approaches in protein sciences and protein engineering to better understand the biochemical, biophysical, and structural functional properties of the biomolecules within the TGF-ß superfamily that drive the signaling pathway. Our efforts contribute to advance innovative research and drug discovery and heavily support our discovery pipeline. You will have the opportunity to learn about early-stage drug discovery from a protein chemistry perspective and collaborate with other departments. You will play an important role supporting in vivo and in vitro studies crucial for the progress of our therapeutic research programs by generating high-quality proteins and other reagents in this hands-on laboratory position. The successful candidate will produce and evaluate novel molecules, while being inquisitive about science and able to troubleshoot by consulting literature / colleagues, and adapt to scientific challenges.

Primary Responsibilities

• Design novel protein molecules and variants, leveraging computational and molecular biology approaches to optimize functional properties and achieve desired binding characteristics.
• Support protein production efforts, including expression in mammalian systems, purification to achieve high-quality reagents using FPLC, affinity, ion-exchange, and SEC chromatography, and continuous optimization of production methods for novel biomolecules.
• Develop and optimize a comprehensive suite of protein characterization assays and techniques, including cell-based, SPR, BLI, SDS-PAGE, analytical SEC, and HPLC, to rigorously evaluate and select promising lead molecules.
• Ensure accurate documentation of all computational and experimental laboratory work within electronic lab notebooks and study reports.
• Effectively communicate research findings through presentations and written reports at research meetings.

Core Competencies (Required Skills)

Preferred Skills

Education Requirements

Diversity, Equity & Inclusion

Keros is an inclusive company. We believe that diversity drives innovation and we continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. We take a holistic approach in mentoring, coaching, and developing all members of our team. Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Recruitment & Staffing Agencies

Keros Therapeutics does not accept unsolicited resumes from agencies. Any unsolicited submission by an agency without a signed contract or expressed consent by a member of the Human Resources Department will be considered the property of Keros Therapeutics, and no fee shall be owed.

Seniority level

Employment type

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