Talent.com
Sr Scientist / Principal Investigator- Oligonucleotide Bioanalysis

Sr Scientist / Principal Investigator- Oligonucleotide Bioanalysis

RPM ReSearchSaint Louis, MO, US
30+ days ago
Job type
  • Full-time
  • Permanent
Job description

Job Description

Job Description

Position Title

Senior Scientist / Principal Investigator -Oligonucleotide Bioanalysis

We are inviting an accomplished scientist to join our growing drug discovery DMPK and Small Molecule Bioanalysis team. Our site has grown to 120 employees and our team has grown to 8 scientists. We have developed a collaborative culture and mutual respect. Our site is part of a 2400 person growing publicly traded international organization with over 15 sites. We recently made a $4.5MM investment in our site.

The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology, and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

This position will be part of a newly created group at our site supporting groups at another site. In the beginning, there will be one person at the site. The goal is to grow the group and this would become a contributing leadership position of the newly formed group.

Objectives :

  • Independently designs and implements novel Bio / -analytical methods to support research projects relating to the development of antisense or siRNA Oligonucleotide based therapeutics.
  • Develop and implement innovative high-resolution mass spectrometry-bases metabolite profiling and identification assays.
  • Act as an oligonucleotide bio / -analytical SME and work cross-functionally to build internal capabilities.

Position Requirements

Education and experience

  • BS or equivalent degree in Chemistry, Biochemistry, or related field, and greater than 15 years of Analytical and / or Bioanalytical Chemistry laboratory experience including study management or,
  • MS in Chemistry, Biochemistry, or related field, and 7 to 10 years of Analytical and / or Bioanalytical Chemistry laboratory experience including study management or,
  • Ph.D. in Chemistry, Biochemistry, or related field and 3 to 5 years of Analytical and / or Bioanalytical Chemistry laboratory experience including study management
  • 5-10 years specific experience with Oligonucleotides
  • Skills and abilities

  • Proven track record of scientific contributions in the development of oligonucleotide analytical and bioanalytical methods to support oligonucleotide delivery platform development.
  • Demonstrates inter-disciplinary knowledge of drug discovery (in vitro / in vivo pharmacology, ADME, PK / PD, translational research, and toxicology)
  • Working knowledge and awareness of general laboratory procedures.
  • Displays versatility and accuracy performing laboratory operations, some of which may be difficult and / or non-routine.
  • Strong and effective manager and mentor of junior scientists
  • Ability to use a computer to compile and maintain databases for records and inventory, utilizing the appropriate software.
  • Ability to adhere to all safety regulations and procedures.
  • In-depth knowledge and specific understanding of analytical testing needed in drug discovery as it relates to quantitating, characterizing, and further understanding the metabolic fate of ASO and siRNA-based therapeutics and conjugates thereof.
  • Support LC-MS instruments operation, daily maintenance, and troubleshooting.
  • An attitude for quality, an eye for detail, the ability to follow written instructions and work with a minimum of supervision.
  • Full and comprehensive benefits package including Medical / Dental / Vision insurance, 401k, bonus potential, and vacation.

    This role is a full-time permanent position.

    Create a job alert for this search

    Principal Scientist • Saint Louis, MO, US

    Related jobs
    • Promoted
    • New!
    Travel Vascular Technologist - $1929 / Week

    Travel Vascular Technologist - $1929 / Week

    Fusion Medical StaffingFestus, MO, US
    Full-time
    Fusion Medical Staffing is seeking an experienced Vascular Technologist for an exciting Travel Allied job in Festus, MO.Shift : Inquire Start Date : 10 / 27 / 2025 Duration : 13 weeks Pay : $1929 / Week.Tr...Show moreLast updated: 3 hours ago
    • Promoted
    Travel Nurse RN - Cardiac Catheterization Lab - $3,143 per week in Shiloh, IL

    Travel Nurse RN - Cardiac Catheterization Lab - $3,143 per week in Shiloh, IL

    TravelNurseSourceShiloh, IL, US
    Full-time +1
    TravelNurseSource is working with Prime Staffing to find a qualified Cath Lab RN in Shiloh, Illinois, 62269!.Cardiac Catheterization Lab or similar critical care setting. Active State or Compact RN ...Show moreLast updated: 1 day ago
    • Promoted
    Travel Nurse RN - Cardiac Catheterization Lab - $2,712 per week in Belleville, IL

    Travel Nurse RN - Cardiac Catheterization Lab - $2,712 per week in Belleville, IL

    TravelNurseSourceBelleville, IL, US
    Full-time
    TravelNurseSource is working with GetMed Staffing to find a qualified Cath Lab RN in Belleville, Illinois, 62226!.GetMed Staffing is searching for a strong Cath Lab RN to assist our traveler-friend...Show moreLast updated: 1 day ago
    • Promoted
    CRNA - Anesthesiology job available in Saint Peters, Missouri

    CRNA - Anesthesiology job available in Saint Peters, Missouri

    RecruitWellCity of Saint Peters, MO, US
    Permanent
    Peters, Missouri, CRNA Job Opportunity.Do you know someone that might be a good fit for this position? Please ask about our generous referral fees!. Competitive compensation and signing incentives.M...Show moreLast updated: 30+ days ago
    • Promoted
    Travel CT Tech - $2573 / Week

    Travel CT Tech - $2573 / Week

    Fusion Medical StaffingBelleville, IL, US
    Full-time
    Fusion Medical Staffing is seeking an experienced CT Tech for an exciting Travel Allied job in Belleville, IL.Shift : Inquire Start Date : 10 / 20 / 2025 Duration : 13 weeks Pay : $2573 / Week.Facility in ...Show moreLast updated: 27 days ago
    • Promoted
    Ultrasound Technologist - PRN - Mercy Jefferson

    Ultrasound Technologist - PRN - Mercy Jefferson

    MercyFestus, MO, United States
    Part-time
    We bring to life a healing ministry through our compassionate care and exceptional service.Join us and discover why Modern Healthcare Magazine named us in its “Top 100 Places to Work.Loan Repayment...Show moreLast updated: 7 days ago
    • Promoted
    Travel Nurse - RN - MS - Medical Surgical - $2326 / Week

    Travel Nurse - RN - MS - Medical Surgical - $2326 / Week

    Coast Medical ServiceRed Bud, IL, US
    Full-time
    Coast Medical Service is seeking an experienced Medical Surgical Registered Nurse for an exciting Travel Nursing job in Red Bud, IL. Shift : 3x12 hr nights Start Date : 10 / 27 / 2025 Duration : 13 weeks P...Show moreLast updated: 1 day ago
    • Promoted
    Nuclear Med Technologist - PRN - Mercy Hospital Jefferson

    Nuclear Med Technologist - PRN - Mercy Hospital Jefferson

    MercyFestus, MO, US
    Full-time
    We’re a Little Different.We bring to life a healing ministry through our compassionate care and exceptional service.Join us and discover why Modern Healthcare Magazine named us in its “...Show moreLast updated: 1 day ago
    • Promoted
    Travel Surgical Tech - $2004.45 / Week

    Travel Surgical Tech - $2004.45 / Week

    AMN Healthcare AlliedO'Fallon, IL, US
    Full-time
    AMN Healthcare Allied is seeking an experienced Surgical Tech for an exciting Travel Allied job in O'Fallon, IL.Shift : 8 hr days Start Date : 11 / 10 / 2025 Duration : 13 weeks Pay : $2004.Job Description...Show moreLast updated: 1 day ago
    • Promoted
    Mammography Technologist II - Part-Time / Days - Mercy Jefferson

    Mammography Technologist II - Part-Time / Days - Mercy Jefferson

    MercyFestus, MO, United States
    Part-time
    We bring to life a healing ministry through our compassionate care and exceptional service.Join us and discover why Modern Healthcare Magazine named us in its “Top 100 Places to Work.Provides scree...Show moreLast updated: 14 days ago
    • Promoted
    Ultrasound Technologist III- Part-Time-Mercy Jefferson

    Ultrasound Technologist III- Part-Time-Mercy Jefferson

    MercyFestus, MO, United States
    Part-time
    We bring to life a healing ministry through our compassionate care and exceptional service.Join us and discover why Modern Healthcare Magazine named us in its “Top 100 Places to Work.Provide diagno...Show moreLast updated: 14 days ago
    • Promoted
    Manager-Lab Operations (Microbiology)

    Manager-Lab Operations (Microbiology)

    MercySaint Louis, MO, US
    Full-time
    We bring to life a healing ministry through our compassionate care and exceptional service.At Mercy, we believe in careers that match the unique gifts of unique individuals careers that not only m...Show moreLast updated: 28 days ago
    • Promoted
    Travel Nurse RN - Med Surg

    Travel Nurse RN - Med Surg

    TrustaffRed Bud, IL, US
    Full-time
    Trustaff is seeking a travel nurse RN Med Surg for a travel nursing job in Red Bud, Illinois.Job Description & Requirements. As a Medical-Surgical (MS) RN, you'll be responsible for managing...Show moreLast updated: 11 days ago
    • Promoted
    • New!
    Travel Ultrasonographer - $2136.6 / Week

    Travel Ultrasonographer - $2136.6 / Week

    Host HealthcareFestus, MO, US
    Full-time
    Host Healthcare is seeking an experienced Ultrasonographer for an exciting Travel Allied job in Festus, MO.Shift : 12 hr days Start Date : 10 / 27 / 2025 Duration : 13 weeks Pay : $2136.At Host Healthcare,...Show moreLast updated: 3 hours ago
    • Promoted
    Special Procedure Technologist II-IR (Non-Exempt)

    Special Procedure Technologist II-IR (Non-Exempt)

    MercyFestus, MO, United States
    Full-time
    We bring to life a healing ministry through our compassionate care and exceptional service.Join us and discover why Modern Healthcare Magazine named us in its “Top 100 Places to Work.Works closely ...Show moreLast updated: 14 days ago
    • Promoted
    Travel Cath Lab Tech - $1932.5 / Week

    Travel Cath Lab Tech - $1932.5 / Week

    Host HealthcareFestus, MO, US
    Full-time
    Host Healthcare is seeking an experienced Cath Lab Tech for an exciting Travel Allied job in Festus, MO.Shift : 8 hr days Start Date : 10 / 06 / 2025 Duration : 13 weeks Pay : $1932.At Host Healthcare, we ...Show moreLast updated: 30+ days ago
    • Promoted
    Travel CT Tech

    Travel CT Tech

    Fusion Medical StaffingShiloh, IL, US
    Full-time
    Fusion Medical Staffing is seeking an experienced CT Tech for an exciting Travel Allied job in Shiloh, IL.Shift : Inquire Start Date : 10 / 20 / 2025 Duration : 13 weeks. Fusion Medical Staffing is seeking...Show moreLast updated: 17 days ago
    • Promoted
    Mammography Technologist, PRN

    Mammography Technologist, PRN

    MercyFestus, MO, United States
    Part-time
    We bring to life a healing ministry through our compassionate care and exceptional service.Join us and discover why Modern Healthcare Magazine named us in its “Top 100 Places to Work.Under the dire...Show moreLast updated: 30+ days ago