Molecular and Cell Biology Principal Research Scientist, Targeted Drug Delivery

Overview

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases.

Position

The Principal Research Scientist will focus on targeted drug delivery including nucleic acid therapies. This role will be on-site at our state-of-the-art research site in San Diego. The successful candidate will have extensive expertise in receptor biology and targeted delivery in extrahepatic tissues / cells, which is instrumental in the development of novel therapeutics.

Key Duties and Responsibilities

• Develop and implement strategic plans for receptor & ligand identification, characterization, optimization, and application in drug discovery.
• Execute research plans, collect and interpret data, troubleshoot, and define next steps.
• Collaborate with cross-functional partners (medicinal chemistry, computational genomics, molecular and cellular biology, pharmacology, protein sciences) to support integrated drug discovery programs from target validation through lead optimization.
• Apply innovative approaches and stay current with advances in receptor biology, ligand discovery, and nucleic acid therapeutics to strengthen pipeline opportunities.
• Prepare and present data in project team meetings, contributing scientific insight and recommendations to guide program strategy.
• Maintain high standards of scientific rigor, accurate documentation, data integrity, and compliance with regulatory guidelines.

Knowledge and Skills

Education and Experience

Flex Designation : On-Site

Flex Eligibility Status : On-Site designated role, five days per week on-site with ad hoc flexibility.

Note : The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Pay Range

$136,000 - $204,000

Disclosure Statement

The range provided is based on a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on factors such as skills, competencies, experience, and other factors permitted by law. From Vertex, total rewards include benefits such as medical, dental, vision, generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, commuting subsidy, charitable donations matching, 401(k) and more.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Applicants requiring an accommodation in connection with the hiring process and / or to perform the essential functions of the position should contact the recruiter or hiring manager, or email Talent Acquisition at ApplicationAssistance@vrtx.com.

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