Population Science Therapeutic Area Lead

The Position

The Population Science Therapeutic Area Lead (PS TAL) is a key role that anchors population science within Genentechs clinical development process across priority therapeutic areas (TAs). Sitting at the intersection of clinical science, data strategy, and real-world impact, the PS TAL ensures development programs are rooted in population-level insights that enhance scientific rigor, clinical relevance, and equitable access.

As a senior scientific advisor and strategic partner within their TA of expertise, the PS TAL is responsible for integrating epidemiologic evidence, real-world data, structured frameworks, and diverse patient perspectives into clinical study design and evidence generation planningat the asset, program, disease area, and TA levels. The PS TALs work informs a deeper understanding of variation in disease burden, diagnosis, treatment patterns, and outcomes across patient populations, helping to guide a comprehensive and effective development strategies.

The PS TAL plays a leading role in cultivating and growing relationships and partnerships with health systems, community partners, and data networks to strengthen the representativeness of both clinical trials and real-world data assets. This includes partnering with internal and external stakeholders to identify and address structural barriers to participation and visibility in the evidence base. The TAL will contribute to thought leadership through scientific publications, forums, and strategic alliances that elevate population science as a critical enabler of innovation and broad health impact.

This individual works closely with stakeholders across the Genentech R&D organization (gRED, pRED, PD, GPS, U.S. Medical Affairs, and Population Health), as well as the Population Science Strategy team, to translate insights into actionable recommendations that strengthen clinical trial design, medical plans, and regulatory strategy. The PS TAL is also a core member of the Population Science leadership team, shaping enterprise strategy and evolving internal standards and approaches across the organization.

You have deep scientific expertise and systems-level thinking; demonstrated strategic and operational leadership across complex cross-functional settings

You are committed to increasing the representation of underserved patient populations in trials and data systems. This will be done by regularly contributing to leadership forums, driving key deliverables aligned with Population Science goals, and helps evolve the field of population science internally and externally.

You will embed broad based research and population science principles into all stages of clinical development by incorporating epidemiologic variation, genetic and social determinants, biomarkers, clinical course, treatment patterns / response and risk-benefit profiles across subgroups (e.g., race, ethnicity, sex, age, and genetic ancestry) into core documents and strategies such as protocols, Disease Area Strategies, Clinical Development Plans, Medical Plans and Integrated Evidence Plans working with asset, project and DA teams.

You will ensure integration of these insights into the clinical development process by proactively identifying and prioritizing high-impact interventions by leveraging population data insights; you will ensure scientific consistency and alignment across clinical, medical, and commercial planning within the TA, collaborating closely with Clinical Science, GPS TA Heads, GDLs, LCLs, and US Medical teams.

You will drive thought leadership by authoring and coordinating scientific publications and lead the incorporation of Population Science principles into key TA-specific congresses, external engagements.

You will champion the integration of population science into Roches innovation & leadership narrative, bringing external credibility and visibility to the enterprises broad based and comprehensive research efforts. You will guide TA teams and leadership on how to embed population science insights into clinical strategy and long-range planning, ensuring their influence extends beyond any single asset or program.

You will work closely with Data and Reporting partners to ensure tracking and reporting of Population Science-related metrics and outcomes across the portfolio, enabling accountability, performance visibility, compliance, and continuous improvement. You will provide regular progress updates to senior governance forums across the enterprise (e.g., LSPC, PDLT, USLT), articulating the value, risks, and impact of Population Science work.

You will provide interpretive guidance on data insights to inform decisions across the clinical development lifecycle. You will serve as a scientific thought partner to clinical teams and GPS partners translating population science insights into clinical development strategies and commercial narratives. You will provide guidance to TA leadership in integrating Population Science considerations and internal and external insights clinical and Medical planning, risk assessments, and long-range strategies.

You will mentor colleagues and rising leaders on the application of population science principles in study planning and execution.

You will co-develop and deliver educational initiatives that build organizational fluency in population science, comprehensive research, and data-driven decision-making.

You will represent corporate thought leadership in key external forums (e.g., industry consortia, academic partnerships, regulatory workshops) to shape the evolving dialogue on broad based research and population science. Develop and sustain relationships with global KOLs, community stakeholders, patient advocates, etc. to inform TA-specific strategies. You will incorporate external experts / expertise into Advisory Boards and Steering Committees to inform strategic direction and enhance scientific credibility

Who You Are : Required :

You have an advanced degree (MD, PharmD, Masters, PhD, or equivalent) in a clinical, biomedical, epidemiological, or population science or health discipline.

You have 20+ years of experience in clinical research, drug development, or applied population science in the biopharmaceutical industry; you have demonstrated expertise in designing or analyzing clinical trials for subgroup differences

You have a deep understanding of population science and the scientific and ethical considerations in clinical research; Familiarity with global regulatory frameworks and global research expectations (e.g., FDA, EMA, ICH).

You have a demonstrated record of external engagement and collaboration with cross-sector stakeholders including an established KOL network.

You have proven leadership and oversight of teams in cross-functional settings and the ability to influence senior stakeholders without direct authority.

Preferred :

You have demonstrated experience working within the Immunology, Ophthalmology, Oncology / Hematology and / or Neuroscience therapeutic areas.

You have excellent communication & presentation skills, including outstanding written and verbal skills

You have strong existing relationships in healthcare and are able to leverage them to support new opportunities; you have experience leading or scaling scientific or strategic teams across therapeutic areas or business units

You have experience working with real-world data sources and applying advanced analytics or machine learning. You have a solid understanding of health disparities, social epidemiology, or community-engaged research.

This position is based in South San Francisco, CA or Basel, Switzerland. This is an on-site role.

Relocation benefits are not being offered for this position.

The expected salary range for this position based on the primary location of South San Francisco, CA is $224,500 - $417,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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