Research Lab Tech Lead

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The General Hospital Corporation

Job Summary

We are seeking an experienced Research Technologist to lead our noninvasive fetal sequencing project (NIFS). Standard noninvasive prenatal testing (NIPT) relies on cell‑free DNA (cfDNA) analysis from maternal plasma but is restricted to detecting common aneuploidies and some microdeletions. We have developed a high‑resolution, noninvasive fetal sequencing approach that can detect clinically significant fetal variants with comparable accuracy to NIPT, eliminating the procedural risk of invasive testing. The candidate will be responsible for optimizing our current NIFS protocol and validating results against the current diagnostic gold standard.

Essential Functions

• Perform DNA / RNA extraction from blood samples (whole blood, buffy coat, plasma).
• Execute molecular genomics procedures as needed (sequencing library production, target hybridization, RNAseq, sample archiving, tissue culture, etc.).
• Learn and perform advanced molecular genomics techniques, including single‑cell RNAseq, ATACseq, ChIPseq, HiC, and other methods.
• Independently perform non‑routine, highly specialized experimental procedures.
• Participate in the design and modification of research protocols.
• Develop research methodologies within experimental parameters and objectives.
• Compose and may present sections of research reports and manuscripts.
• Perform advanced data analysis using statistical techniques.
• Oversee and coordinate lab activities, including quality assurance and scheduling.
• Troubleshoot problems and instruct others in specialized techniques.

Qualifications

Education

Experience

Knowledge, Skills, and Abilities

Technical Skills

EEO Statement

The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and / or other status protected under law. We will provide reasonable accommodation to individuals with disabilities to participate in the application or interview process and to perform essential functions of the job.

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