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Scientist II-Bioanalysis
Scientist II-BioanalysisUS Tech Solutions, Inc. • South San Francisco, California, US
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Scientist II-Bioanalysis

Scientist II-Bioanalysis

US Tech Solutions, Inc. • South San Francisco, California, US
5 days ago
Job type
  • Temporary
Job description

Duration : 6 months contract

Not sure what skills you will need for this opportunity Simply read the full description below to get a complete picture of candidate requirements.

Description :

  • The Quantitative, Translational ADME Sciences (QTAS) department is seeking a highly motivated Scientist to join the Biologics bioanalysis, characterization, and proteomics group. The main function of this position is to develop and implement LC / MS (liquid chromatography / mass spectrometry)-based bioanalysis and in vitro characterization assays for biologics entities. The successful candidate will be experienced in the development, optimization and implementation and routine LC / MS-based bioanalytical methods to support in vivo PK, TK, and PK / PD studies as well as in vitro stability characterization of therapeutic proteins, peptides, and oligonucleotides. The candidate will be responsible for sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation.

Responsibilities :

  • Operate and maintain LC / MS instruments to generate high-quality experimental data.
  • Perform affinity purification of therapeutic proteins (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices.
  • Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
  • Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.
  • Communicate data interpretation internally and externally.

    • Skills :

  • Highly motivated, self-driven and results-oriented with communication and presentation skills; capable of working both as a team player and individual contributor.
  • Prior industry experience in drug discovery / development is preferred. In-depth understanding of PK, TK and PK / PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired.
  • Experience on routine LC / MS-based bioanalysis to support in vivo PK, TK, and PK / PD studies .
  • Hands-on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and / or Orbitrap (Thermo) mass spectrometers highly desired.
  • Hands-on experience with automated liquid handling systems highly desired.
  • Hands-on experience with oligonucleotide analysis highly desired.

    • Education and experience :

  • BS degree in Chemistry, Pharmacology or other related fields with 3+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on mass spectrometry, or PhD degree .

    • About US Tech Solutions :

    US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.

    US Tech Solutions is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

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    Scientist • South San Francisco, California, US