PK/PD Modeling / Pharmacometrics LeadMercor • Honolulu, Hawaii, US

PK / PD Modeling / Pharmacometrics Lead

Mercor • Honolulu, Hawaii, US

22 hours ago

Job type

Part-time

Remote

Job description

This person complements the client’s “Translational / Clinical Pharmacology Decision-Maker” team by grounding dose selection and exposure–response analysis in

quantitative structure and parameter plausibility

###

Who we’re looking for

Deep hands-on experience in

PK, PD, exposure–response modeling

, and ideally

population PK or QSP

. - Expert at model fitting, sensitivity analysis, and identifying non-plausible parameter spaces. - Can evaluate the validity of dose–exposure predictions and detect high-risk extrapolations. - Comfortable designing

model evaluation rubrics

that distinguish between acceptable vs. non-credible outputs. - Able to articulate how quantitative checks should complement narrative decision logic.

Nice-to-have :

Experience supporting translational or clinical pharmacology leads in dose justification. - Familiarity with integrating nonclinical PK / PD data (2-species GLP → human FIH extrapolation). ###

Experience level

~8–12 years of quantitative pharmacology experience in

pharma, CROs, or modeling consultancies

. - Strong portfolio in

population PK / PD

exposure–response

, and

parameter estimation

using NONMEM, Monolix, or equivalent tools. - Demonstrated ability to interpret model results for decision-making, not just fit data. - Can create

fit-for-purpose models

and critique model structures or assumptions under uncertainty. ###

Expectations

Design and refine

micro-evaluations

for PK / PD performance (curve fits, parameter checks, error taxonomies). - Encode

quantitative sanity checks

into model rubrics for automated evaluation. - Define

failure conditions

(e.g., unsafe extrapolation, poor coverage curves, invalid assumptions).

Inputs we give :

PK / PD datasets, tox summaries, and performance prompts (e.g., “fit exposure–response curves, interpret safety margins”). - Example model outputs from automated systems.

Expected outputs :

Quantitative Rubrics :

clear thresholds for acceptable parameter fits, coverage curve quality, and model integrity checks. -

Golden Fit Examples :

representative “ideal” PK / PD model outputs and visualizations for calibration. -

Error Taxonomy :

structured list of typical modeling or fitting errors, with root-cause annotations. -

Meta-Layer Commentary :

short note per rubric capturing how expert modelers recognize implausible or unsafe fits beyond numeric error values. ###

Engagement Model & Compensation

Contract / part-time

, remote, outcome-based deliverables.

Create a job alert for this search

Modeling • Honolulu, Hawaii, US

Related jobs

Neurology – Independent Practice Track (MedCBO Supported)

MedCBO, Inc • Honolulu, HI, United States

Full-time

Neurology – Independent Practice Track (MedCBO Supported).MedCBO is a Colorado-based healthcare business infrastructure company that empowers independent physician groups across the United States t...Show more

Last updated: 13 days ago • Promoted

LMFT or LMHC-Crisis & Triage Management - Part Time 32 hours

Kaiser • WAIPAHU, Hawaii, United States

Part-time

Work as part of a team in the Crisis and Triage Advice Line to provide telephonic triage, screening and crisis intervention for members seeking behavioral health services.Provide ambulatory behavio...Show more

Last updated: 30+ days ago • Promoted

Network Pricing Consultant - Remote

UnitedHealth Group • Honolulu, HI, United States

Remote

Full-time

At UnitedHealthcare, we're simplifying the health care experience, creating healthier communities and removing barriers to quality care. The work you do here impacts the lives of millions of people ...Show more

Last updated: 17 days ago • Promoted

Supervisor, Provider Research

HMSA • Honolulu, HI, United States

Full-time

Manage staff, ensuring provider inquiries are responded to timely, accurately, and professionally.Resolve complex provider inquiries. Respond to and oversee staff responding to CMS demand letters.Pa...Show more

Last updated: 9 days ago • Promoted

Senior Project Manager - Oncology / Hematology (Phase III)

Syneos Health / inVentiv Health Commercial LLC • Honolulu, HI, United States

Full-time

Senior Project Manager - Oncology / Hematology (Phase III).Syneos Health is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success.We translate uniqu...Show more

Last updated: 21 days ago • Promoted

Clinical Product Manager Medical Device Safety & Usability

Hawaii Staffing • Honolulu, HI, US

Full-time

Clinical Product Manager (Medical Device Focus).Oracle Health is standing up a specialized clinical product management team focused on medical devicealigned products. This team bridges clinical prac...Show more

Last updated: 16 days ago • Promoted

Clinical Trial Manager (Phase 3)

Crinetics Pharmaceuticals • Honolulu, HI, US

Full-time

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with rare endocrine diseases. We were founded by a dedicated team of scientists with...Show more

Last updated: 2 days ago • Promoted

Travel Cath Lab Tech - $3120 / Week

Uniti Med • Honolulu, HI, US

Full-time

Uniti Med is seeking an experienced Cath Lab Tech for an exciting Travel Allied job in Honolulu, HI.Shift : Inquire Start Date : 12 / 15 / 2025 Duration : 13 weeks Pay : $3120 / Week.Uniti Med provides car...Show more

Last updated: 30+ days ago • Promoted

Travel RN - PICU - Pediatric Intensive Care - Honolulu, Hawaii - $3341 / week

Vetted Health • Honolulu, HI, United States

Temporary

Job Opportunity : RN - PICU - Pediatric Intensive Care.Specialty : RN - PICU - Pediatric Intensive Care.Facility : Coast Medical Service. Coordinates total nursing care for patients.Participates in pat...Show more

Last updated: 2 days ago • Promoted

DPT / Physical Therapist - Acute and Outpatient Care

MLee Healthcare Staffing and Recruiting, Inc • Honolulu, HI, United States

Full-time

Transform Lives with Every Step : Join Our Physical Therapy Team in Enchanting Honolulu.Imagine a world where your everyday dedication helps someone regain their balance after surgery, reclaim their...Show more

Last updated: 30+ days ago • Promoted

Field Medical Director, Pain Management

Evolent • Honolulu, HI, United States

Full-time

Evolent partners with health plans and providers to achieve better outcomes for people with most complex and costly health conditions. Working across specialties and primary care, we seek to connect...Show more

Last updated: 4 days ago • Promoted

Sr Statistical R Programmer (North America Only)

Syneos Health / inVentiv Health Commercial LLC • Honolulu, HI, United States

Full-time

Sr Statistical R Programmer (North America Only).Syneos Health is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success.We translate unique clin...Show more

Last updated: 1 day ago • Promoted

DPT - Hospital / Clinic Physical Therapist

MLee Healthcare Staffing and Recruiting, Inc • Honolulu, HI, United States

Full-time

Empower Healing in Beautiful Honolulu : Join Our Inpatient Physical Therapy Team.Imagine using your expertise to help someone take that crucial first step after surgery, restore their independence f...Show more

Last updated: 30+ days ago • Promoted

Data Modeler - Manager - Consulting - Miami / South Florida

EY • Honolulu, HI, United States

Full-time

At EY, we're all in to shape your future with confidence.We'll help you succeed in a globally connected powerhouse of diverse teams and take your career wherever you want it to go.Join EY and help ...Show more

Last updated: 3 days ago • Promoted

Pharmacy Performance Analyst

HMSA • Honolulu, HI, United States

Full-time

Provides quality, objective, and professional analysis of relevant topics.Gathers and analyzes information to identify trends, issues, innovations, and solutions for priority business needs.Develop...Show more

Last updated: 30+ days ago • Promoted

Sr Regulatory Associate PM (NA or LATAM Based Only)

Syneos Health / inVentiv Health Commercial LLC • Honolulu, HI, United States

Full-time

Sr Regulatory Associate PM (NA or LATAM Based Only).Syneos Health is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success.We translate unique cli...Show more

Last updated: 1 day ago • Promoted

Medical Director - Clinical Advocacy and Support - Remote

UnitedHealth Group • Honolulu, HI, United States

Remote

Full-time

Optum is a global organization that delivers care, aided by technology to help millions of people live healthier lives.The work you do with our team will directly improve health outcomes by connect...Show more

Last updated: 30+ days ago • Promoted

Travel RN - PICU - Pediatric Intensive Care - Honolulu, Hawaii - $2916 / week

Vetted Health • Honolulu, HI, United States

Temporary

Job Opportunity : RN - PICU - Pediatric Intensive Care.Specialty : RN - PICU - Pediatric Intensive Care.Coordinates total nursing care for patients. Participates in patient and family teaching.Provide...Show more

Last updated: 3 days ago • Promoted