Director, Medicinal Chemistry

SUMMARY

Reporting to the Senior Director, Medicinal Chemistry, the Director role is a key leadership position within HotSpot’s drug discovery programs. The successful candidate will co‑lead a discovery program team in close partnership with a lead biologist, driving strategic and scientific direction. This hybrid role, based in Boston’s Seaport District, offers a high degree of flexibility.

RESPONSIBILITIES

Lead medicinal chemistry efforts in collaboration with biology and cross‑functional partners to advance programs from hit identification through clinical candidate nomination.

Design new compounds for synthesis.

Leverage advanced modeling techniques and utilize computational tools for structure‑based drug design and lead optimization.

Manage external chemistry resources (CROs), overseeing synthesis activities, timelines, and scientific direction to ensure quality and timely delivery.

Work with a matrixed team in computational chemistry, ADME, pharmacology, and process chemistry to deliver high‑quality output.

Present key data, conclusions, and recommendations to project teams and senior management effectively and concisely; support preparation of board and business‑development materials.

QUALIFICATIONS

Ph.D. degree in organic chemistry or medicinal chemistry and a minimum of 10+ years of relevant experience in small‑molecule drug discovery within a pharmaceutical and / or biotech setting.

Previous experience in chemical methodology and / or total synthesis.

Driven, self‑motivated, and proactive; able to independently identify objectives, design strategies, and execute plans to achieve goals.

Effective mentor and communicator; able to lead scientific discussions and influence project direction within a collaborative, matrixed environment.

Comfortable working within a distributed team model including use of Zoom or other video‑conference tools.

Ability to integrate data / input from different sources and team members.

Deep expertise in synthetic chemistry and structure‑based drug design.

Experience leading medicinal chemistry efforts within cross‑functional discovery teams.

Strong track record of peer‑reviewed publications and / or patent filings.

OUR BENEFITS

Competitive salary and discretionary bonus plans.

Medical, dental, vision plans and fringe benefits.

Generous paid holidays, time off, including 2 company‑wide shutdowns.

Hybrid, flexible work model : approx. 2 days per week on site.

Amazing team of supportive colleagues.

At HotSpot, we have a bold mission to establish a new drug discovery paradigm. If this appeals to you, please let us know at iatimcurious@hotspotthera.com.

HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

At this time, HotSpot is not able to offer visa sponsorship for this position. Candidates must be authorized to work in the United States without current or future sponsorship.

#Courageous Adventurers #Leave your Mark #Keep it Human #Make it Real

#J-18808-Ljbffr