Senior Scientist - Protein Design and Engineering

Job Description

Job Description

Salary : $120K to $150K

About Us

Monod Bio is a pioneer company in the design ofde novoprotein reagents for Life Sciences and Diagnostics. Our innovative design platform technology takes advantage of the most recent advances in deep learning computational protein engineering to create highly rapid and sensitive protein-based reagents and assays.Our visionary founding team and state-of-the-art technology and product development experience position Monod Bio at the forefront of molecular reporter, binder and functional protein innovation, and we welcome exceptional individuals to join us in this journey.

About the Role

We are currently seeking a Senior Scientist Protein Design and Engineering to help us lead the development of next-generation de novo protein reagents. This individual will drive protein design efforts from concept through implementation, working closely with a multidisciplinary team of computational designers, assay developers, and protein engineers. The ideal candidate will have deep expertise in molecular biology, protein engineering, and biophysical characterization, along with a track record of success developing novel protein-based technologies.

Key Responsibilities

• Lead the design, screening, and characterization of de novo protein reagents across a range of applications, from conceptualization through downstream implementation and validation.
• Design and execute protein engineering / directed evolution campaigns strategiesincluding structure-guided design, directed evolution, and mutagenesis workflowsto improve target binding affinity, stability, and selectivity.
• Collaborate cross-functionally to align project objectives, timelines, and design needs with downstream applications.
• Guide the development and screening of DNA libraries using yeast surface display or other display technologies (e.g., phage), including FACS-based selection and flow cytometry analysis.
• Oversee molecular biology workflows including cloning, site-directed mutagenesis, and high-throughput construct assembly.
• Characterize designed proteins using biophysical and biochemical techniques, including binding kinetics (SPR, BLI), thermal stability (DSF / SLS), and secondary structure (CD).
• Contribute to data analysis and interpretation, clearly communicating findings and recommendations to internal teams.
• Maintain detailed experimental records in Benchling and contribute to documentation for internal and external reporting.
• Stay current with advancements in protein design and engineering, bringing new ideas and techniques into the team.

Required Qualifications

Physical environment and key requirements :

We are proud to provide a generous benefits package and a healthy work culture :

Every position requires certain physical capabilities with the major ones for this role noted above. Monod Bio seeks to provide reasonable accommodations that enable individuals with disabilities to perform essential duties when possible. Equal employment opportunity is a fundamental principle at Monod Bio. We are committed to nondiscrimination in all business operations. We are proud to enjoy a respectful and inclusive work environment where everyone has the opportunity to thrive.