Therapeutic Area Biomarker Lead (Renal) - Associate Director or Director

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Summary

#LI-Hybrid

Internal Title : Associate Director or Director

As a Therapeutic Area Biomarker Lead (TABL), leading areas related to renal diseases you will lead project matrix teams of Biomarker Leads (leading at clinical project level) and subject matter experts and support clinical projects as the Biomarker Lead. Biomarkers are critical components of translational research, enabling robust therapeutic and mechanistic hypothesis testing in early and late clinical development, and as precision medicine enablers covering the potential contexts of use e.g. confirm target engagement and pathway modulation, assess efficacy and response, PD / PK and dose selection, safety, disease modification, patient selection or stratification, and compound differentiation that directly support program decision making.

The Biomarker Development (BMD), within Translational Medicine in Novartis, is a dedicated group of >

150 associates who deliver innovative biomarker solutions for clinical studies. BMD expertise spans the spectrum of biomarker modalities including imaging, digital healthcare technologies, soluble / cellular / molecular, data analytics and operations working in partnerships with the therapeutic area (TA) teams to develop, communicate and implement biomarker, translational science and translational data strategies and plans with the clinical teams and decision boards.

About the Role

Key Responsibilities :

Acting as BMD's strategic and scientific leader within the renal portfolio to lead fit for purpose clinical biomarker strategies and plans, translational sciences, data, and precision medicine approaches for their portfolio in partnership with key stakeholders including clinical development, research, and other translational medicine functions.

Leading efforts to identify, develop, and drive disease, mechanistic and compound biology that serves the clinical and precision medicine approaches for the multi-indication portfolio. Is responsible for the contextualization and interpretation of the biomarker data.

Leading or co-leading, where relevant, enterprise-wide cross functional teams around above assets strategies, indication or pathway task forces or working groups, translational data, precision medicine etc.

Leading a dedicated matrixed group of biomarker leads (leading at project level) and Subject Matter Experts, as well as key program partners, to together develop biomarkers strategies for disease and / or assets across the Research-Development-Commercial continuum.

Acting as Biomarker Lead on clinical projects to drive biomarker and precision medicine strategy at the compound level.

Representing BMD on decision boards meetings, and clinical protocol review for their projects.

Developing deep understanding of the translational biomarkers for a project, focused on compound, disease, target, and pathway biology.

With our data science leads, leading strategic translational data efforts centered on integrating and analyzing large-scale patient muti-modal data sets (omics, imaging, digital, etc.).

Providing thought leadership with other BMD therapeutic area TABLs to identify alignments and drive innovation across assets, indications, and therapeutic areas.

Reporting to Therapeutic Area Biomarker Head (TABH) and cooperating closely to enable the development of disease area / indication / project level biomarker strategy and plans, implementation, contextualizing, and interpretation.

Acting as an enterprise partner and strategic leader in a matrix environment; integrating and representing projects in the internal / external scientific discussions and initiatives.

Staying up to date on clinical, disease, biology and scientific literature for their respective disease areas or indications.

Essential Requirements :

This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will require approximately 5% travel as defined by the business (domestic and / or international).

Minimum 3-5 years (Associate Director level) and 10 years (Director level) of experience with deep understanding of any of the following areas : renal biology, immunology, auto-immune diseases, genetic diseases or related areas. As well as strong translational research, drug development and clinical biomarkers that can be applied to questions of target and pathway engagement, patient's selection, enrichment, dose selection, efficacy and response, disease progression, among others.

PhD, MD, PharmD, MD / PhD, or equivalent degrees with relevant experience

Pharmaceutical industry experience is strongly preferred.

Scientific excellence as supported by academic and / or industry career track, and / or high-quality publications; clinical and / or biological expertise in renal biology, autoimmune disease, genetic diseases, or related areas.

Experience and familiarity with quantitative research and data is strongly preferred, including expertise in genetics and omics profiling, clinical imaging, machine learning, genetics or data science.

Proven success in leading and partnering in multidisciplinary matrix teams across Pharma, biotech, academic institutions, or commercial business functions.

Well-developed interpersonal and leadership skills with strong presence and ability to influence and navigate large organizational structures.

This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.

The salary for this position is expected to range :

Associate Director : between $145,600 and $270,400 per year.

Director : between $185,500 and $344,500 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

To learn more about the culture, rewards and benefits we offer our people click here.

Why Novartis :

Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? https : / / www.novartis.com / about / strategy / people-and-culture

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Benefits and Rewards :

Read our handbook to learn about all the ways we'll help you thrive personally and professionally : https : / / www.novartis.com / careers / benefits-rewards

EEO Statement :

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

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