Downstream Processing Technician

Downstream Processing Technician

Job Description

The Downstream Processing Technician will support the manufacture of commercial and clinical biologics by performing operations in accordance with Current Good Manufacturing Practices (cGMPs). The role involves a variety of functions related to downstream purification and filtration / HPLC, including propagation of mammalian cell culture, aseptic cell culture operations, and execution of large-scale production bioreactors ranging from 50L to 2000L. Responsibilities also include large-scale filtration, centrifugation, and chromatography.

Responsibilities

Review all area documents and ensure accuracy.

Assist in the manufacture of controls and calibrators, completing batch records following cGMPs.

Perform in-process assays using equipment such as spectrophotometers, pH meters, and clinical analyzers.

Weigh, transfer, and mix chemicals as required.

Conduct product filtrations and maintain cleanliness of equipment.

Clean and steam steel tanks using CIP / SIP processes.

Prepare glassware and steel tanks for sterilization in autoclave and operate the autoclave.

Maintain and calibrate lab equipment, including pumps, pH meters, and flow meters.

Monitor stocks of common lab supplies and respond to emergency notifications.

Work flexible hours, including weekends, and perform other job duties as required.

Essential Skills

Minimum of 2 years of work experience in manufacturing, operation, production, lab setting or related field.

Bachelor's Degree in a STEM-related field.

Knowledge of cGMP practices and aseptic techniques.

Experience with downstream processing steps and chemical concepts.

Additional Skills & Qualifications

6 months of experience in a GMP regulated environment preferred.

Experience in aseptic technique, chromatography, and HPLC.

Preferred : A 4-year STEM degree.

Subject Matter Expert on downstream processing steps.

Work Environment

The work environment includes cleanrooms and aseptic suites where the technician must be willing to gown up. Day shifts are from 6 : 15 am to 6 : 45 pm, on a rotating 12-hour schedule, working 7 days over a 2-week period. Employees must wear full gowning suits including bodysuits, gloves, hair & beard nets, face covers, and safety glasses. Personal items such as makeup, jewelry, nail polish, cologne / perfume, and scented lotions or hair care products are prohibited. The role requires the ability to lift at least 25 lbs independently and to stand for 80% of the shift.

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Job Type & Location

This is a Contract to Hire position based out of Saint Louis, MO.

Pay and Benefits

The pay range for this position is $28.00 - $28.00 / hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following :

• Medical, dental & vision - Critical Illness, Accident, and Hospital - 401(k) Retirement Plan - Pre-tax and Roth post-tax contributions available - Life Insurance (Voluntary Life & AD&D for the employee and dependents) - Short and long-term disability - Health Spending Account (HSA) - Transportation benefits - Employee Assistance Program - Time Off / Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Saint Louis,MO.

Application Deadline

This position is anticipated to close on Nov 24, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email actalentaccommodation@actalentservices.com (%20actalentaccommodation@actalentservices.com) for other accommodation options.