Senior DevOps Engineer

Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary-a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset : talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion-every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong.

We are seeking a highly skilled Senior DevOps Engineer to help us integrate security practices within our DevOps pipeline while managing and developing secure, scalable solutions on Amazon Web Services (AWS). The ideal candidate will have a strong background in both security and system administration, with expertise in AWS infrastructure and the ability to automate security controls, monitor vulnerabilities, and implement secure coding practices across the entire software development lifecycle. You will work closely with development, operations, and security teams to ensure that our products and infrastructure are secure, resilient, and compliant.

Responsibilities :

• AWS Infrastructure Management : Design, build, and maintain scalable, secure infrastructure on AWS, leveraging services like EC2, ECS / EKS, Lambda, RDS, S3, VPC, IAM, and Route 53
• Infrastructure as Code (IaC) : Automate provisioning and management using Terraform, CloudFormation, or Ansible; ensure infrastructure is defined, versioned, and secured according to best practices
• CI / CD Pipeline Security : Implement and secure continuous integration and deployment pipelines, ensuring security in every stage from development through production
• Security Integration : Integrate security practices into the development lifecycle-baking in secure coding, vulnerability monitoring, and automated controls across the SDLC
• Monitoring & Observability : Develop and maintain dashboards and alerts using DataDog, AWS CloudWatch, CloudTrail, GuardDuty, and Config; track vulnerabilities, incidents, and system performance
• Day-to-Day Operations : Support user account management, troubleshooting, and system monitoring to ensure uptime and reliability
• Collaboration : Partner with development, operations, and security teams to define and enforce security best practices, policies, and procedures
• Incident Response : Assist with detection, analysis, and response efforts to resolve issues quickly and thoroughly
• Compliance & Governance : Ensure environments comply with industry regulations and internal security policies (HIPAA, SOC 2, GDPR, PCI DSS, CLIA, CAP)

Qualifications :

Nice-To-Haves :

Benefits And Perks :

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary / equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of $279,089 per year, including a base pay range of $168,961 - $190,081 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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About BillionToOne

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA-a breakthrough that's already transformed the lives of over half a million patients worldwide.

Our Impact : We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete™ stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth : From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition : Forbes recently named us one of America's Best Startup Employers for 2025 , and we were awarded Great Place to Work certification in 2024 -with an incredible 100% of our people reporting they are willing to give extra to get the job done . These honors recognize not just our innovation but the exceptional culture we've cultivated-one that remains authentically collaborative and transparent even as we've scaled.

Our Future : Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started.

At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work.

Ready to help us change the world, one diagnosis at a time?

Learn more at www.billiontoone.com